open access

Vol 60, No 4 (2009)
Original papers
Published online: 2009-06-26
Submitted: 2013-02-15
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Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes

Saeed Sadeghian, Mohammad Ali Boroumand, Maryam Sotoudeh-Anvari, Shahram Rabbani, Mahmood Sheikhfathollahi, Ali Abbasi
Endokrynologia Polska 2009;60(4):258-262.

open access

Vol 60, No 4 (2009)
Original papers
Published online: 2009-06-26
Submitted: 2013-02-15

Abstract


Background: This experimental study was performed to determine the impact of opium use on serum lipid profile and glucose metabolism in rats with streptozotocin-induced diabetes.
Material and methods: To determine the effect of opium, 20 male rats were divided into control (n = 10) and opium-treated (n = 10) groups. After diabetes induction, the animals were investigated for daily glucose measurements for 35 days. Serum lipid profile and haemoglobin A1c (HbA1c) were assayed at the baseline (before induction of diabetes) and at 35-day follow-up.
Results: The glycaemia levels in the rats treated with opium were similar to the levels measured in the control rats (544.8 ± 62.2 mg/dl v. 524.6 ± 50.0 mg/dl, P = 0.434). In addition, there was no difference between the opium-treated rats and control rats in HbA1c (6.5 ± 0.5% v. 6.6 ± 0.2%, P = 0.714). Compared to the control rats, the serum total cholesterol, high density lipoprotein (HDL), triglyceride and lipoprotein (a) in the test animals were similar.
Conclusion: Opium use has no significant effect on glucose metabolism and serum lipid profile in rats with induced diabetes.

Abstract


Background: This experimental study was performed to determine the impact of opium use on serum lipid profile and glucose metabolism in rats with streptozotocin-induced diabetes.
Material and methods: To determine the effect of opium, 20 male rats were divided into control (n = 10) and opium-treated (n = 10) groups. After diabetes induction, the animals were investigated for daily glucose measurements for 35 days. Serum lipid profile and haemoglobin A1c (HbA1c) were assayed at the baseline (before induction of diabetes) and at 35-day follow-up.
Results: The glycaemia levels in the rats treated with opium were similar to the levels measured in the control rats (544.8 ± 62.2 mg/dl v. 524.6 ± 50.0 mg/dl, P = 0.434). In addition, there was no difference between the opium-treated rats and control rats in HbA1c (6.5 ± 0.5% v. 6.6 ± 0.2%, P = 0.714). Compared to the control rats, the serum total cholesterol, high density lipoprotein (HDL), triglyceride and lipoprotein (a) in the test animals were similar.
Conclusion: Opium use has no significant effect on glucose metabolism and serum lipid profile in rats with induced diabetes.
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Keywords

opium; STZ-diabetic rats; glucose; lipid

About this article
Title

Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes

Journal

Endokrynologia Polska

Issue

Vol 60, No 4 (2009)

Pages

258-262

Published online

2009-06-26

Bibliographic record

Endokrynologia Polska 2009;60(4):258-262.

Keywords

opium
STZ-diabetic rats
glucose
lipid

Authors

Saeed Sadeghian
Mohammad Ali Boroumand
Maryam Sotoudeh-Anvari
Shahram Rabbani
Mahmood Sheikhfathollahi
Ali Abbasi

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