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Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes
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Abstract
Background: This experimental study was performed to determine the impact of opium use on serum lipid profile and glucose metabolism in rats with streptozotocin-induced diabetes.
Material and methods: To determine the effect of opium, 20 male rats were divided into control (n = 10) and opium-treated (n = 10) groups. After diabetes induction, the animals were investigated for daily glucose measurements for 35 days. Serum lipid profile and haemoglobin A1c (HbA1c) were assayed at the baseline (before induction of diabetes) and at 35-day follow-up.
Results: The glycaemia levels in the rats treated with opium were similar to the levels measured in the control rats (544.8 ± 62.2 mg/dl v. 524.6 ± 50.0 mg/dl, P = 0.434). In addition, there was no difference between the opium-treated rats and control rats in HbA1c (6.5 ± 0.5% v. 6.6 ± 0.2%, P = 0.714). Compared to the control rats, the serum total cholesterol, high density lipoprotein (HDL), triglyceride and lipoprotein (a) in the test animals were similar.
Conclusion: Opium use has no significant effect on glucose metabolism and serum lipid profile in rats with induced diabetes.
Abstract
Background: This experimental study was performed to determine the impact of opium use on serum lipid profile and glucose metabolism in rats with streptozotocin-induced diabetes.
Material and methods: To determine the effect of opium, 20 male rats were divided into control (n = 10) and opium-treated (n = 10) groups. After diabetes induction, the animals were investigated for daily glucose measurements for 35 days. Serum lipid profile and haemoglobin A1c (HbA1c) were assayed at the baseline (before induction of diabetes) and at 35-day follow-up.
Results: The glycaemia levels in the rats treated with opium were similar to the levels measured in the control rats (544.8 ± 62.2 mg/dl v. 524.6 ± 50.0 mg/dl, P = 0.434). In addition, there was no difference between the opium-treated rats and control rats in HbA1c (6.5 ± 0.5% v. 6.6 ± 0.2%, P = 0.714). Compared to the control rats, the serum total cholesterol, high density lipoprotein (HDL), triglyceride and lipoprotein (a) in the test animals were similar.
Conclusion: Opium use has no significant effect on glucose metabolism and serum lipid profile in rats with induced diabetes.
Keywords
opium; STZ-diabetic rats; glucose; lipid
About this articleTitle
Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes
Journal
Issue
Article type
Original paper
Pages
258-262
Published online
2009-06-26
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860
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1650
Bibliographic record
Endokrynol Pol 2009;60(4):258-262.
Keywords
opium
STZ-diabetic rats
glucose
lipid
Authors
Saeed Sadeghian
Mohammad Ali Boroumand
Maryam Sotoudeh-Anvari
Shahram Rabbani
Mahmood Sheikhfathollahi
Ali Abbasi
