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open access

Vol 60, No 5 (2009)
Postgraduate education
Published online: 2009-10-30
Submitted: 2013-02-15
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Chromogranin A (CgA) - characteristic of the currently available laboratory methods and conditions which can influence the results

Piotr Glinicki, Wojciech Jeske
Endokrynologia Polska 2009;60(5):415-419.

open access

Vol 60, No 5 (2009)
Postgraduate education
Published online: 2009-10-30
Submitted: 2013-02-15

Abstract

Chromogranin A is a main, nonspecific neuroendocrine tumor marker (NET). It’s estimation was applied for diagnostic purposes and for monitoring the treatment of NET. Currently few commercial assays are available allowing measurement of CgA concentration in serum or plasma. These methods have various sensitivity and specificity and differ in many analitycal parameters. Numerous factors and pathologies may influence the outcome of the CgA measurement. Therefore, a review article on this matter may be useful for clinical and laboratory practice.

Abstract

Chromogranin A is a main, nonspecific neuroendocrine tumor marker (NET). It’s estimation was applied for diagnostic purposes and for monitoring the treatment of NET. Currently few commercial assays are available allowing measurement of CgA concentration in serum or plasma. These methods have various sensitivity and specificity and differ in many analitycal parameters. Numerous factors and pathologies may influence the outcome of the CgA measurement. Therefore, a review article on this matter may be useful for clinical and laboratory practice.

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Keywords

chromogranin A; CgA-IRMA; CgA-RIA; CgA-ELISA; neuroendocrine tumors

About this article
Title

Chromogranin A (CgA) - characteristic of the currently available laboratory methods and conditions which can influence the results

Journal

Endokrynologia Polska

Issue

Vol 60, No 5 (2009)

Pages

415-419

Published online

2009-10-30

Bibliographic record

Endokrynologia Polska 2009;60(5):415-419.

Keywords

chromogranin A
CgA-IRMA
CgA-RIA
CgA-ELISA
neuroendocrine tumors

Authors

Piotr Glinicki
Wojciech Jeske

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