open access

Vol 60, No 5 (2009)
Case report
Published online: 2009-10-30
Submitted: 2013-02-15
Get Citation

Two cases of serious hepatic injury caused by antithyroid drugs

Marek Grzywa, Renata Orłowska-Florek, Anna Grzywa-Celińska
Endokrynologia Polska 2009;60(5):396-400.

open access

Vol 60, No 5 (2009)
Case report
Published online: 2009-10-30
Submitted: 2013-02-15

Abstract

We present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due to intolerance. The main symptom was jaundice lasting about 2 months. As a first step in the treatment we terminated the antithyroid drug administration and introduced prednisone and ursodesoksycholic acid therapy. The termination of thyrotoxicosis by means of 131 I administration had also positive influence on the course of disease. In summary we emphasise the significance of prompt discontinuation of antithyroid drug once toxic symptoms appeared and avoid replacement one thyrostatic drug for another in fovour of radioiodine treatment.

Abstract

We present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due to intolerance. The main symptom was jaundice lasting about 2 months. As a first step in the treatment we terminated the antithyroid drug administration and introduced prednisone and ursodesoksycholic acid therapy. The termination of thyrotoxicosis by means of 131 I administration had also positive influence on the course of disease. In summary we emphasise the significance of prompt discontinuation of antithyroid drug once toxic symptoms appeared and avoid replacement one thyrostatic drug for another in fovour of radioiodine treatment.
Get Citation

Keywords

antithyroid drugs; liver toxicity; radioiodine

About this article
Title

Two cases of serious hepatic injury caused by antithyroid drugs

Journal

Endokrynologia Polska

Issue

Vol 60, No 5 (2009)

Pages

396-400

Published online

2009-10-30

Bibliographic record

Endokrynologia Polska 2009;60(5):396-400.

Keywords

antithyroid drugs
liver toxicity
radioiodine

Authors

Marek Grzywa
Renata Orłowska-Florek
Anna Grzywa-Celińska

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