open access

Vol 61, No 1 (2010)
Original papers
Published online: 2010-03-04
Submitted: 2013-02-15
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Melatonin, the RANKL/RANK/OPG system, and bone metabolism in girls with anorexia nervosa

Zofia Ostrowska, Katarzyna Ziora, Beata Kos-Kudła, Elżbieta Świętochowska, Joanna Oświęcimska, Antoni Dyduch, Kinga Wołkowska-Pokrywa, Bożena Szapska
Endokrynologia Polska 2010;61(1):117-123.

open access

Vol 61, No 1 (2010)
Original papers
Published online: 2010-03-04
Submitted: 2013-02-15

Abstract


Introduction: Young women and girls with anorexia nervosa (AN) suffer from abnormalities in melatonin (MEL) secretion, especially in the nocturnal phase. This is paralleled by a considerable bone mass loss and abnormalities of bone metabolism. As melatonin has been implicated in playing a role in inducing osteoporosis and that the effect could be mediated by the RANKL/RANK/OPG system, we decided to investigate the potential associations between MEL and bone status in girls with AN. Aim: To evaluate the relationship between MEL, bone metabolism (as assessed by serum levels of bone turnover markers [OC and CTx]), and OPG and sRANKL in girls with AN.
Material and methods: A total of 57 girls with AN and 13 healthy girls, between 13 and 18 years of age, were enrolled in the study, and we evaluated BMI, fasting levels of OC, CTx, OPG and sRANKL, and levels of MEL (fasting levels and the levels at 2 a.m., at which time the secretion of the hormone peaks).
Results: We found a significantly increased mean serum level of MEL at 2 a.m. and an increased amplitude between nocturnal and morning levels of the hormone in girls with AN. We also showed a considerable suppression of the mean OC and CTx levels and an increase in serum OPG and RANKL levels paralleled by a significantly reduced OPG/sRANKL ratio. The changes in the MEL levels at 2 a.m. showed a statistically significant negative correlation with levels of the bone markers and a positive correlation with sRANKL. The changes in the amplitude between the nocturnal and morning levels of MEL showed a negative correlation with CTx levels and the OPG/sRANKL ratio.
Conclusions: Our results indicate that the abnormalities of bone metabolism in girls with AN are associated with changes in the nocturnal levels of MEL with RANKL appearing to play an important role in this mechanism. The increased amplitude between the nocturnal and morning levels of MEL may adversely affect the bone tissue in girls with AN with the effect most likely resulting from influences on the OPG/RANKL balance.
(Pol J Endocrinol 2010; 61 (1): 117-123)

Abstract


Introduction: Young women and girls with anorexia nervosa (AN) suffer from abnormalities in melatonin (MEL) secretion, especially in the nocturnal phase. This is paralleled by a considerable bone mass loss and abnormalities of bone metabolism. As melatonin has been implicated in playing a role in inducing osteoporosis and that the effect could be mediated by the RANKL/RANK/OPG system, we decided to investigate the potential associations between MEL and bone status in girls with AN. Aim: To evaluate the relationship between MEL, bone metabolism (as assessed by serum levels of bone turnover markers [OC and CTx]), and OPG and sRANKL in girls with AN.
Material and methods: A total of 57 girls with AN and 13 healthy girls, between 13 and 18 years of age, were enrolled in the study, and we evaluated BMI, fasting levels of OC, CTx, OPG and sRANKL, and levels of MEL (fasting levels and the levels at 2 a.m., at which time the secretion of the hormone peaks).
Results: We found a significantly increased mean serum level of MEL at 2 a.m. and an increased amplitude between nocturnal and morning levels of the hormone in girls with AN. We also showed a considerable suppression of the mean OC and CTx levels and an increase in serum OPG and RANKL levels paralleled by a significantly reduced OPG/sRANKL ratio. The changes in the MEL levels at 2 a.m. showed a statistically significant negative correlation with levels of the bone markers and a positive correlation with sRANKL. The changes in the amplitude between the nocturnal and morning levels of MEL showed a negative correlation with CTx levels and the OPG/sRANKL ratio.
Conclusions: Our results indicate that the abnormalities of bone metabolism in girls with AN are associated with changes in the nocturnal levels of MEL with RANKL appearing to play an important role in this mechanism. The increased amplitude between the nocturnal and morning levels of MEL may adversely affect the bone tissue in girls with AN with the effect most likely resulting from influences on the OPG/RANKL balance.
(Pol J Endocrinol 2010; 61 (1): 117-123)
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Keywords

melatonin; bone status; anorexia nervosa; girls

About this article
Title

Melatonin, the RANKL/RANK/OPG system, and bone metabolism in girls with anorexia nervosa

Journal

Endokrynologia Polska

Issue

Vol 61, No 1 (2010)

Pages

117-123

Published online

2010-03-04

Bibliographic record

Endokrynologia Polska 2010;61(1):117-123.

Keywords

melatonin
bone status
anorexia nervosa
girls

Authors

Zofia Ostrowska
Katarzyna Ziora
Beata Kos-Kudła
Elżbieta Świętochowska
Joanna Oświęcimska
Antoni Dyduch
Kinga Wołkowska-Pokrywa
Bożena Szapska

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