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Bone mineral density and metabolism in levothyroxine-treated adolescent girls with euthyroid diffuse goiter
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Abstract
Introduction: Bone and mineral metabolism is influenced by thyroid hormones, and levothyroxine (LT4) therapy may be associated with reduced bone mass in postmenopausal women.
Material and methods: The aim of the study was to assess the influence of one year of LT4 treatment in a group of 21 adolescent girls with euthyroid diffuse goiter. Lumbar (L2-L4) and total body bone mineral density (TOBMD) (Lunar - DXA), serum PTH, osteocalcin, bone alkaline phosphate, vitamin D3, calcium, and phosphorus levels and urinary excretion of Ca, P, and hydroxyproline were measured before and after one year of combined LT4 and iodine treatment.
Results: Patients were matched for age, sex, BMI, and maturation status, with controls treated with iodine only. Markers of bone turnover changed in a similar manner in both groups. There was no significant difference in TOBMD value after one year of therapy between LT4 treated group and controls. Densitometric lumbar spine parameters increased significantly after 12 months in both groups, with no significant differences between them.
Conclusion: It can be concluded that one year of LT4 treatment of adolescent girls with euthyroid diffuse goiter does not have a negative impact on their bone remodelling and metabolism.
(Pol J Endocrinol 2010; 61 (1): 14-19)
Abstract
Introduction: Bone and mineral metabolism is influenced by thyroid hormones, and levothyroxine (LT4) therapy may be associated with reduced bone mass in postmenopausal women.
Material and methods: The aim of the study was to assess the influence of one year of LT4 treatment in a group of 21 adolescent girls with euthyroid diffuse goiter. Lumbar (L2-L4) and total body bone mineral density (TOBMD) (Lunar - DXA), serum PTH, osteocalcin, bone alkaline phosphate, vitamin D3, calcium, and phosphorus levels and urinary excretion of Ca, P, and hydroxyproline were measured before and after one year of combined LT4 and iodine treatment.
Results: Patients were matched for age, sex, BMI, and maturation status, with controls treated with iodine only. Markers of bone turnover changed in a similar manner in both groups. There was no significant difference in TOBMD value after one year of therapy between LT4 treated group and controls. Densitometric lumbar spine parameters increased significantly after 12 months in both groups, with no significant differences between them.
Conclusion: It can be concluded that one year of LT4 treatment of adolescent girls with euthyroid diffuse goiter does not have a negative impact on their bone remodelling and metabolism.
(Pol J Endocrinol 2010; 61 (1): 14-19)
Keywords
euthyroid diffuse goiter; children; levothyroxine; bone mineral density; bone turnover markers
About this articleTitle
Bone mineral density and metabolism in levothyroxine-treated adolescent girls with euthyroid diffuse goiter
Journal
Issue
Article type
Original paper
Pages
14-19
Published online
2010-03-04
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589
Article views/downloads
2165
Bibliographic record
Endokrynol Pol 2010;61(1):14-19.
Keywords
euthyroid diffuse goiter
children
levothyroxine
bone mineral density
bone turnover markers
Authors
Paweł Matusik
Ewa Małecka-Tendera
Edward Franek
Aleksandra Januszek-Trzciąkowska
