open access

Vol 61, No 2 (2010)
Original papers
Published online: 2010-05-12
Submitted: 2013-02-15
Get Citation

Adipose tissue activity in relation to overweight or obesity

Maria Gnacińska, Sylwia Małgorzewicz, Marek Guzek, Wiesława Łysiak-Szydłowska, Krzysztof Sworczak
Endokrynologia Polska 2010;61(2):160-168.

open access

Vol 61, No 2 (2010)
Original papers
Published online: 2010-05-12
Submitted: 2013-02-15

Abstract


Introduction: Obesity is associated with a number of diseases resulting from the excessive amount of adipose tissue. The aim of this study was to investigate the correlation between the quantity of adipose tissue and the prevalence of metabolic disturbances, and the concentration of adipokines and proinflammatory cytokines in obese or overweight patients.
Material and methods: 25 kg/m2 took part in this study. Twenty-three healthy people with normal BMI formed the control group. Twenty-one people from the study group were on a low-calorie diet. All subjects underwent anthropometric assessment, laboratory investigations, and blood-pressure examination.
Results: Patients with obesity or overweight, in comparison to those with normal BMI, showed insulin resistance and a higher concentration of high sensitivity C-reactive protein (hs-CRP), plasminogen activator inhibitor 1 (PAI-1), and interleukin 6 (Il-6). The concentration of adiponectin was significantly lower in this group. The patients on the low-calorie diet had significantly lower concentrations of leptin when compared to other obese people; moreover, a trend towards decreased hs-CRP concentration was seen. A significant positive correlation between leptin and hs-CRP was observed. The serum concentration of adiponectin was inversely correlated with that of TNF-α, IL-6, hs-CRP, and PAI-1.
Conclusions: The results of this study may suggest the beneficial impact of a low-calorie diet on the slowing down of inflammatory processes. The observed negative correlation between the concentrations of adiponectin and inflammatory cytokines may confirm the anti-inflammatory activity of this adipokine.
(Pol J Endocrinol 2010; 61 (2): 160-168)

Abstract


Introduction: Obesity is associated with a number of diseases resulting from the excessive amount of adipose tissue. The aim of this study was to investigate the correlation between the quantity of adipose tissue and the prevalence of metabolic disturbances, and the concentration of adipokines and proinflammatory cytokines in obese or overweight patients.
Material and methods: 25 kg/m2 took part in this study. Twenty-three healthy people with normal BMI formed the control group. Twenty-one people from the study group were on a low-calorie diet. All subjects underwent anthropometric assessment, laboratory investigations, and blood-pressure examination.
Results: Patients with obesity or overweight, in comparison to those with normal BMI, showed insulin resistance and a higher concentration of high sensitivity C-reactive protein (hs-CRP), plasminogen activator inhibitor 1 (PAI-1), and interleukin 6 (Il-6). The concentration of adiponectin was significantly lower in this group. The patients on the low-calorie diet had significantly lower concentrations of leptin when compared to other obese people; moreover, a trend towards decreased hs-CRP concentration was seen. A significant positive correlation between leptin and hs-CRP was observed. The serum concentration of adiponectin was inversely correlated with that of TNF-α, IL-6, hs-CRP, and PAI-1.
Conclusions: The results of this study may suggest the beneficial impact of a low-calorie diet on the slowing down of inflammatory processes. The observed negative correlation between the concentrations of adiponectin and inflammatory cytokines may confirm the anti-inflammatory activity of this adipokine.
(Pol J Endocrinol 2010; 61 (2): 160-168)
Get Citation

Keywords

obesity; adipokines; inflammation

About this article
Title

Adipose tissue activity in relation to overweight or obesity

Journal

Endokrynologia Polska

Issue

Vol 61, No 2 (2010)

Pages

160-168

Published online

2010-05-12

Bibliographic record

Endokrynologia Polska 2010;61(2):160-168.

Keywords

obesity
adipokines
inflammation

Authors

Maria Gnacińska
Sylwia Małgorzewicz
Marek Guzek
Wiesława Łysiak-Szydłowska
Krzysztof Sworczak

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl