open access

Vol 61, No 3 (2010)
Review article
Published online: 2010-07-02
Submitted: 2013-02-15
Get Citation

Molecular physiology of cellular glucose transport - a potential area for clinical studies in diabetes mellitus

Jan Tatoń, Paweł Piątkiewicz, Anna Czech
Endokrynologia Polska 2010;61(3):303-310.

open access

Vol 61, No 3 (2010)
Review article
Published online: 2010-07-02
Submitted: 2013-02-15

Abstract

The normalization of cellular glucose assimilation is the basic aim of metabolic therapy in type 2 diabetes mellitus (T2DM). It requires parallel changes in the process of cellular glucose transport (CGT).
This review presents the pathophysiological and clinical outlines of CGT. Sequentially, the advances in the mechanisms and classification of CGT and their physiological and molecular base are described. The role of CGT pathogenetic significance in diabetes mellitus is stressed. Finally, the opinion is expressed that the CGT study is a potentially important approach to clinical interpretation of glucose metabolism disturbances and their pharmacotherapy.
(Pol J Endocrinol 2010; 61 (3): 303-310)

Abstract

The normalization of cellular glucose assimilation is the basic aim of metabolic therapy in type 2 diabetes mellitus (T2DM). It requires parallel changes in the process of cellular glucose transport (CGT).
This review presents the pathophysiological and clinical outlines of CGT. Sequentially, the advances in the mechanisms and classification of CGT and their physiological and molecular base are described. The role of CGT pathogenetic significance in diabetes mellitus is stressed. Finally, the opinion is expressed that the CGT study is a potentially important approach to clinical interpretation of glucose metabolism disturbances and their pharmacotherapy.
(Pol J Endocrinol 2010; 61 (3): 303-310)
Get Citation

Keywords

cellular glucose transport; insulin; action-signalling pathway; diabetes mellitus

About this article
Title

Molecular physiology of cellular glucose transport - a potential area for clinical studies in diabetes mellitus

Journal

Endokrynologia Polska

Issue

Vol 61, No 3 (2010)

Pages

303-310

Published online

2010-07-02

Bibliographic record

Endokrynologia Polska 2010;61(3):303-310.

Keywords

cellular glucose transport
insulin
action-signalling pathway
diabetes mellitus

Authors

Jan Tatoń
Paweł Piątkiewicz
Anna Czech

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