open access

Vol 61, No 3 (2010)
Review article
Published online: 2010-07-02
Submitted: 2013-02-15
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Cellular glucose transport disturbances in the pathogenesis and therapy of type 2 diabetes mellitus

Anna Czech, Jan Tatoń, Paweł Piątkiewicz
Endokrynologia Polska 2010;61(3):292-302.

open access

Vol 61, No 3 (2010)
Review article
Published online: 2010-07-02
Submitted: 2013-02-15

Abstract

The current world epidemic of type 2 diabetes mellitus results from two general groups of causative factors. One is the influence of strong pathogenetic environmental pressures - also described as negative civilizational influence - on the very large subpopulation, assessed at 30% of the total world population, which is genetically predisposed to react to this external stress with the symptoms of type 2 diabetes mellitus. Such a pathogenetic reaction is based on the appearance of cellular and organ resistance to insulin. A second factor involves the beta cells of the pancreatic islets and their dysfunction.
For these reasons, studies on the aetiology of insulin resistance have significance, both theoretical and practical. There are many biological deviations that can produce cellular insulin resistance and underutilization of glucose. The mechanism that is always present is the decrease of cellular glucose transport. For this reason, it should be approached as a potential target for preventive and therapeutic actions. These pathophysiological and clinical circumstances were the motivation for presenting a review of cellular glucose transport pathophysiology, which contributes to the aetiology of insulin resistance, cellular underutilization of glucose, and type 2 diabetes mellitus. They underline the significance of cellular glucose transport as a target for prevention and therapy of type 2 diabetes mellitus and other insulinresistant conditions.
This review presents comments about the influence on cellular glucose transport of diet, physical exercise, and pharmacotherapeutic agents, based on the authors’ studies. The review could contribute to an innovative approach to the pathogenesis, prevention, and therapy of type 2 diabetes mellitus and other conditions related to insulin resistance.
(Pol J Endocrinol 2010; 61 (3): 292-302)

Abstract

The current world epidemic of type 2 diabetes mellitus results from two general groups of causative factors. One is the influence of strong pathogenetic environmental pressures - also described as negative civilizational influence - on the very large subpopulation, assessed at 30% of the total world population, which is genetically predisposed to react to this external stress with the symptoms of type 2 diabetes mellitus. Such a pathogenetic reaction is based on the appearance of cellular and organ resistance to insulin. A second factor involves the beta cells of the pancreatic islets and their dysfunction.
For these reasons, studies on the aetiology of insulin resistance have significance, both theoretical and practical. There are many biological deviations that can produce cellular insulin resistance and underutilization of glucose. The mechanism that is always present is the decrease of cellular glucose transport. For this reason, it should be approached as a potential target for preventive and therapeutic actions. These pathophysiological and clinical circumstances were the motivation for presenting a review of cellular glucose transport pathophysiology, which contributes to the aetiology of insulin resistance, cellular underutilization of glucose, and type 2 diabetes mellitus. They underline the significance of cellular glucose transport as a target for prevention and therapy of type 2 diabetes mellitus and other insulinresistant conditions.
This review presents comments about the influence on cellular glucose transport of diet, physical exercise, and pharmacotherapeutic agents, based on the authors’ studies. The review could contribute to an innovative approach to the pathogenesis, prevention, and therapy of type 2 diabetes mellitus and other conditions related to insulin resistance.
(Pol J Endocrinol 2010; 61 (3): 292-302)
Get Citation

Keywords

insulin resistance; cellular glucose transport; type 2 diabetes mellitus pathogenesis and therapy

About this article
Title

Cellular glucose transport disturbances in the pathogenesis and therapy of type 2 diabetes mellitus

Journal

Endokrynologia Polska

Issue

Vol 61, No 3 (2010)

Pages

292-302

Published online

2010-07-02

Bibliographic record

Endokrynologia Polska 2010;61(3):292-302.

Keywords

insulin resistance
cellular glucose transport
type 2 diabetes mellitus pathogenesis and therapy

Authors

Anna Czech
Jan Tatoń
Paweł Piątkiewicz

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