open access

Vol 61, No 3 (2010)
Original paper
Submitted: 2013-02-15
Published online: 2010-07-02
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Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot

Nuri Karadurmus, Mustafa Sahin, Canturk Tasci, Ilkin Naharci, Cengiz Ozturk, Savas Ilbasmis, Zeki Dulkadir, Ahmet Sen, Kenan Saglam
Endokrynol Pol 2010;61(3):275-279.

open access

Vol 61, No 3 (2010)
Original Paper
Submitted: 2013-02-15
Published online: 2010-07-02

Abstract


Introduction: The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations.
Material and methods: Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a total of 30 sessions. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), homeostasis model measurement-insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), uric acid, mean platelet volume (MPV), complete blood count, and lipid profile were tested.
Results: Upon completion of treatment, a statistically significant improvement was observed in the mean values of all assessed parameters.
Conclusions: HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT.
(Pol J Endocrinol 2010; 61 (3): 275-279)

Abstract


Introduction: The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations.
Material and methods: Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a total of 30 sessions. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), homeostasis model measurement-insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), uric acid, mean platelet volume (MPV), complete blood count, and lipid profile were tested.
Results: Upon completion of treatment, a statistically significant improvement was observed in the mean values of all assessed parameters.
Conclusions: HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT.
(Pol J Endocrinol 2010; 61 (3): 275-279)
Get Citation

Keywords

hyperbaric oxygen therapy; diabetes; diabetic foot; atherosclerosis; glycaemic control

About this article
Title

Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot

Journal

Endokrynologia Polska

Issue

Vol 61, No 3 (2010)

Article type

Original paper

Pages

275-279

Published online

2010-07-02

Page views

1988

Article views/downloads

4776

Bibliographic record

Endokrynol Pol 2010;61(3):275-279.

Keywords

hyperbaric oxygen therapy
diabetes
diabetic foot
atherosclerosis
glycaemic control

Authors

Nuri Karadurmus
Mustafa Sahin
Canturk Tasci
Ilkin Naharci
Cengiz Ozturk
Savas Ilbasmis
Zeki Dulkadir
Ahmet Sen
Kenan Saglam

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