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Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot
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Abstract
Introduction: The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations.
Material and methods: Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a total of 30 sessions. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), homeostasis model measurement-insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), uric acid, mean platelet volume (MPV), complete blood count, and lipid profile were tested.
Results: Upon completion of treatment, a statistically significant improvement was observed in the mean values of all assessed parameters.
Conclusions: HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT.
(Pol J Endocrinol 2010; 61 (3): 275-279)
Abstract
Introduction: The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations.
Material and methods: Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a total of 30 sessions. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), homeostasis model measurement-insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), uric acid, mean platelet volume (MPV), complete blood count, and lipid profile were tested.
Results: Upon completion of treatment, a statistically significant improvement was observed in the mean values of all assessed parameters.
Conclusions: HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT.
(Pol J Endocrinol 2010; 61 (3): 275-279)
Keywords
hyperbaric oxygen therapy; diabetes; diabetic foot; atherosclerosis; glycaemic control
About this articleTitle
Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot
Journal
Issue
Article type
Original paper
Pages
275-279
Published online
2010-07-02
Page views
1886
Article views/downloads
4674
DOI
10.5603/ep.25378
Bibliographic record
Endokrynol Pol 2010;61(3):275-279.
Keywords
hyperbaric oxygen therapy
diabetes
diabetic foot
atherosclerosis
glycaemic control
Authors
Nuri Karadurmus
Mustafa Sahin
Canturk Tasci
Ilkin Naharci
Cengiz Ozturk
Savas Ilbasmis
Zeki Dulkadir
Ahmet Sen
Kenan Saglam
