open access

Vol 61, No 4 (2010)
Review article
Published online: 2010-08-31
Submitted: 2013-02-15
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Chromogranin A (CgA) - the influence of various factors in vivo and in vitro, and existing disorders on it’s concentration in blood

Piotr Glinicki, Wojciech Jeske
Endokrynologia Polska 2010;61(4):384-387.

open access

Vol 61, No 4 (2010)
Review article
Published online: 2010-08-31
Submitted: 2013-02-15

Abstract

Chromogranin A (CgA) is regarded as a major, nonspecific neuroendocrine tumour (NET) marker. The results of CgA blood concentration, however, may actually be influenced by various factors or coexisting pathological conditions. Among the factors causing a substantial increase of the blood CgA concentration are: treatment with proton-pump inhibitors or H2 -receptor blockers, chronic atrophic gastritis (type A), impaired renal function, prostate cancer and BPH, and rheumatoid arthritis with high level of RF IgM. In addition, the sort of investigated biological material (whether it is serum or plasma) is of importance.
There are also many conditions which may have a moderate or little influence on the concentration of CgA, among them are: inflammatory bowel disease (ulcerative colitis and Crohn’s disease), deteriorating liver function, untreated essential hypertension, heart failure, hypercortisolism, pregnancy, and, in some subjects, ingestion of a meal.
Proper assessment of the CgA results requires detailed knowledge about various factors, drugs, and pathological conditions influencing its concentration in blood. (Pol J Endocrinol 2010; 61 (4): 384-387)

Abstract

Chromogranin A (CgA) is regarded as a major, nonspecific neuroendocrine tumour (NET) marker. The results of CgA blood concentration, however, may actually be influenced by various factors or coexisting pathological conditions. Among the factors causing a substantial increase of the blood CgA concentration are: treatment with proton-pump inhibitors or H2 -receptor blockers, chronic atrophic gastritis (type A), impaired renal function, prostate cancer and BPH, and rheumatoid arthritis with high level of RF IgM. In addition, the sort of investigated biological material (whether it is serum or plasma) is of importance.
There are also many conditions which may have a moderate or little influence on the concentration of CgA, among them are: inflammatory bowel disease (ulcerative colitis and Crohn’s disease), deteriorating liver function, untreated essential hypertension, heart failure, hypercortisolism, pregnancy, and, in some subjects, ingestion of a meal.
Proper assessment of the CgA results requires detailed knowledge about various factors, drugs, and pathological conditions influencing its concentration in blood. (Pol J Endocrinol 2010; 61 (4): 384-387)
Get Citation

Keywords

chromogranin A; neuroendocrine tumours

About this article
Title

Chromogranin A (CgA) - the influence of various factors in vivo and in vitro, and existing disorders on it’s concentration in blood

Journal

Endokrynologia Polska

Issue

Vol 61, No 4 (2010)

Pages

384-387

Published online

2010-08-31

Bibliographic record

Endokrynologia Polska 2010;61(4):384-387.

Keywords

chromogranin A
neuroendocrine tumours

Authors

Piotr Glinicki
Wojciech Jeske

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