open access

Vol 61, No 4 (2010)
Original papers
Published online: 2010-08-31
Submitted: 2013-02-15
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Urine and milk iodine concentrations in healthy and congenitally hypothyroid neonates and their mothers

Mahin Hashemipour, Peyman Nasri, Silva Hovsepian, Rezvane Hadian, Kamal Heidari, Hossein Movahedian Attar, Massoud Amini, Leili Moohebat, Ali Sajadi, Ali Ajami
Endokrynologia Polska 2010;61(4):371-376.

open access

Vol 61, No 4 (2010)
Original papers
Published online: 2010-08-31
Submitted: 2013-02-15

Abstract


Introduction: In view of the high prevalence of Congenital Hypothyroidism (CH) in Iran, in this study we evaluated the role of iodine in the aetiology of CH by comparing urine and milk iodine concentrations in healthy and congenitally hypothyroid neonates and their mothers.
Material and methods: In a cross-sectional study, urinary iodine concentrations (UIC) in newborns with CH, as well as UIC and the milk iodine concentrations (MIC) of their mothers, were measured and compared with a control group. The lower, mid, and upper range of UIC for neonates and lactating mothers was considered to be < 150 mg/L, 150-230 mg/L, and > 230 mg/L, and lower, mid, and upper range of MIC was considered to be < 150 mg/L, 150-180 mg/L, and > 180 mg/L, respectively.
Results: 0.05). The median MIC in the case group was higher than in the control group (210 mg/L v. 170 mg/L, P < 0.05).There was a positive correlation between newborn UIC and MIC. There was no significant correlation between newborn UIC and serum TSH, maternal UIC and maternal MIC, or newborn UIC and serum TSH.
Conclusions: There is no inadequacy in iodine intake in the studied population. Iodine excess could be a possible risk factor for CH, but there were findings, such as lack of correlation between maternal MIC and UIC, and the median neonatal UIC, which was similar in the two groups, so, drawing conclusions should be done with some caution and requires further studies. (Pol J Endocrinol 2010; 61 (4): 371-376)

Abstract


Introduction: In view of the high prevalence of Congenital Hypothyroidism (CH) in Iran, in this study we evaluated the role of iodine in the aetiology of CH by comparing urine and milk iodine concentrations in healthy and congenitally hypothyroid neonates and their mothers.
Material and methods: In a cross-sectional study, urinary iodine concentrations (UIC) in newborns with CH, as well as UIC and the milk iodine concentrations (MIC) of their mothers, were measured and compared with a control group. The lower, mid, and upper range of UIC for neonates and lactating mothers was considered to be < 150 mg/L, 150-230 mg/L, and > 230 mg/L, and lower, mid, and upper range of MIC was considered to be < 150 mg/L, 150-180 mg/L, and > 180 mg/L, respectively.
Results: 0.05). The median MIC in the case group was higher than in the control group (210 mg/L v. 170 mg/L, P < 0.05).There was a positive correlation between newborn UIC and MIC. There was no significant correlation between newborn UIC and serum TSH, maternal UIC and maternal MIC, or newborn UIC and serum TSH.
Conclusions: There is no inadequacy in iodine intake in the studied population. Iodine excess could be a possible risk factor for CH, but there were findings, such as lack of correlation between maternal MIC and UIC, and the median neonatal UIC, which was similar in the two groups, so, drawing conclusions should be done with some caution and requires further studies. (Pol J Endocrinol 2010; 61 (4): 371-376)
Get Citation

Keywords

congenital hypothyroidism; milk; urine; iodine

About this article
Title

Urine and milk iodine concentrations in healthy and congenitally hypothyroid neonates and their mothers

Journal

Endokrynologia Polska

Issue

Vol 61, No 4 (2010)

Pages

371-376

Published online

2010-08-31

Bibliographic record

Endokrynologia Polska 2010;61(4):371-376.

Keywords

congenital hypothyroidism
milk
urine
iodine

Authors

Mahin Hashemipour
Peyman Nasri
Silva Hovsepian
Rezvane Hadian
Kamal Heidari
Hossein Movahedian Attar
Massoud Amini
Leili Moohebat
Ali Sajadi
Ali Ajami

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