Cardiovascular risk factors in relatives of type 2 diabetics with normal glucose tolerance test and elevated one-hour plasma glucose

Abstract

Introduction: To investigate the effect of elevated one hour post-load plasma glucose on cardiovascular risk factors, in normal glucose tolerance (NGT) people, who are first degree relatives of type 2 diabetics.
Material and methods: A cross-sectional study on 1475 NGT subjects (Arian ethnicity), who had one hour post-load plasma glucose was carried out. We compared the mean of age, sex, body mass index, waist circumference, blood pressure, lipid profile, and area under the curve of glucose (AUC-G) of 1190 out of 1475 NGT subjects with one hour plasma glucose (1hpG) ≥ 155 mg/dL, and 285 NGT subjects with 1hpG < 155 mg/dL.
Results: The mean age, body mass index, waist circumference, blood pressure, lipid profile (but not low HDL-cholesterol), and area under the curve of glucose (AUC-G) was significantly higher in NGT subjects with 1hpG ≥ 155 mg/dL (P < 0.05). Normal glucose tolerance people (first degree relatives of type 2 diabetic patients) with 1hpG ≥ 155 mg/dL were older and heavier than those with 1hpG < 155 mg/dL. Cardiovascular risk factors (but not low HDL and hypertension) were more prevalent in those with elevated one hour post-load group (P < 0.05).
Conclusions: NGT subjects with elevated one hour post-load plasma glucose (1hpG ≥ 155 mg/dL) had higher prevalence of most cardiovascular risk factors in comparison with those with 1hpG < 155 mg/dL. (Pol J Endocrinol 2010; 61 (4): 359-363)