open access

Vol 61, No 4 (2010)
Original papers
Published online: 2010-08-31
Submitted: 2013-02-15
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The relationship between ghrelin levels and insulin resistance in men with idiopathic hypogonadotrophic hypogonadism at diagnosis and after therapy

M. Ilkin Naharci, Erol Bolu, Nuri Karadurmus, Yalcin Basaran
Endokrynologia Polska 2010;61(4):351-358.

open access

Vol 61, No 4 (2010)
Original papers
Published online: 2010-08-31
Submitted: 2013-02-15

Abstract


Introduction: It has recently been shown that ghrelin affects energy balance and reproductive function, but the role of ghrelin in the pathogenesis of insulin resistance is unclear. Firstly to assess the interaction between insulin resistance and ghrelin levels in hypogonadal men, and then to show the effects of testosterone (T) therapy on insulin and ghrelin.
Material and methods: Twenty-four male patients newly diagnosed with idiopathic hypogonadotropic hypogonadism (IHH) and 20 healthy male subjects were enrolled in this study. Ghrelin, insulin, glucose, total and free testosterone levels, HOMA-IR and QUICKI, and percentage of body fat mass were determined at baseline in all subjects and after therapy in hypogonadal men.
Results: When compared with control subjects, hypogonadal men had significantly lower total and free T concentrations, ghrelin levels, and QUICKI whereas they had significantly higher body fat mass and HOMA-IR score. Following T therapy, a significant increase in ghrelin and QUICKI, and a decrease in HOMA-IR score and body fat mass were demonstrated in hypogonadal men. Calculation of the Pearson coefficient showed that ghrelin concentrations in hypogonadal men were positively correlated with free and total testosterone and QUICKI, whereas they were negatively correlated with body fat mass and HOMA-IR. After six months of T therapy, these correlations were still observed.
Conclusions: Our data supports the notion that ghrelin may constitute an important link between the regulation of reproduction and metabolic homeostasis. (Pol J Endocrinol 2010; 61 (4): 351-358)

Abstract


Introduction: It has recently been shown that ghrelin affects energy balance and reproductive function, but the role of ghrelin in the pathogenesis of insulin resistance is unclear. Firstly to assess the interaction between insulin resistance and ghrelin levels in hypogonadal men, and then to show the effects of testosterone (T) therapy on insulin and ghrelin.
Material and methods: Twenty-four male patients newly diagnosed with idiopathic hypogonadotropic hypogonadism (IHH) and 20 healthy male subjects were enrolled in this study. Ghrelin, insulin, glucose, total and free testosterone levels, HOMA-IR and QUICKI, and percentage of body fat mass were determined at baseline in all subjects and after therapy in hypogonadal men.
Results: When compared with control subjects, hypogonadal men had significantly lower total and free T concentrations, ghrelin levels, and QUICKI whereas they had significantly higher body fat mass and HOMA-IR score. Following T therapy, a significant increase in ghrelin and QUICKI, and a decrease in HOMA-IR score and body fat mass were demonstrated in hypogonadal men. Calculation of the Pearson coefficient showed that ghrelin concentrations in hypogonadal men were positively correlated with free and total testosterone and QUICKI, whereas they were negatively correlated with body fat mass and HOMA-IR. After six months of T therapy, these correlations were still observed.
Conclusions: Our data supports the notion that ghrelin may constitute an important link between the regulation of reproduction and metabolic homeostasis. (Pol J Endocrinol 2010; 61 (4): 351-358)
Get Citation

Keywords

testosterone replacement therapy; ghrelin; insulin resistance

About this article
Title

The relationship between ghrelin levels and insulin resistance in men with idiopathic hypogonadotrophic hypogonadism at diagnosis and after therapy

Journal

Endokrynologia Polska

Issue

Vol 61, No 4 (2010)

Pages

351-358

Published online

2010-08-31

Bibliographic record

Endokrynologia Polska 2010;61(4):351-358.

Keywords

testosterone replacement therapy
ghrelin
insulin resistance

Authors

M. Ilkin Naharci
Erol Bolu
Nuri Karadurmus
Yalcin Basaran

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