Genetic predisposition to papillary thyroid cancer

Dorota Kula; Michał Kalemba; Beata Jurecka-Lubieniecka; Zbigniew Puch; Małgorzata Kowalska; Tomasz Tyszkiewicz; Monika Kowal; Daria Handkiewicz-Junak

Vol 61, No 5 (2010)

Review paper

Submitted: 2013-02-15

Published online: 2010-11-04

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Genetic predisposition to papillary thyroid cancer

Dorota Kula, Michał Kalemba, Beata Jurecka-Lubieniecka, Zbigniew Puch, Małgorzata Kowalska, Tomasz Tyszkiewicz, Monika Kowal, Daria Handkiewicz-Junak

Endokrynol Pol 2010;61(5):486-489.

Vol 61, No 5 (2010)

Review Article

Submitted: 2013-02-15

Published online: 2010-11-04

Abstract

Approximately 5% of differentiated thyroid cancers are hereditary. Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]). Among FNMTC, PTC is the most common. Although a hereditary predisposition to non-medullary thyroid cancer is well established, the susceptibility genes are poorly known. Up to now, by linkage analysis using microsatellite markers, several putative loci have been described - 1q21, 6q22, 8p23.1-p22, and 8q24; however, validation studies have been unsuccessful. In the present review we discuss the results of linkage analysis and the most recent results of genome wide association studies (GWAS) with high resolution SNP (single nucleotide polymorphism) arrays.
(Pol J Endocrinol 2010; 61 (5): 486-489)