Vol 61, No 5 (2010)
Review paper
Published online: 2010-11-04
Genetic predisposition to papillary thyroid cancer
Endokrynol Pol 2010;61(5):486-489.
Abstract
Approximately 5% of differentiated thyroid cancers are hereditary. Hereditary non-medullary thyroid cancer may occur as a minor component
of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer
[FNMTC]). Among FNMTC, PTC is the most common. Although a hereditary predisposition to non-medullary thyroid cancer is well
established, the susceptibility genes are poorly known. Up to now, by linkage analysis using microsatellite markers, several putative loci
have been described - 1q21, 6q22, 8p23.1-p22, and 8q24; however, validation studies have been unsuccessful. In the present review we
discuss the results of linkage analysis and the most recent results of genome wide association studies (GWAS) with high resolution SNP
(single nucleotide polymorphism) arrays.
(Pol J Endocrinol 2010; 61 (5): 486-489)
(Pol J Endocrinol 2010; 61 (5): 486-489)
Keywords: papillary thyroid carcinomafamilial non-medullary thyroid cancergenetic predispositionSNP
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