open access

Vol 61, No 5 (2010)
Review article
Published online: 2010-11-04
Submitted: 2013-02-15
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Genetic predisposition to papillary thyroid cancer

Dorota Kula, Michał Kalemba, Beata Jurecka-Lubieniecka, Zbigniew Puch, Małgorzata Kowalska, Tomasz Tyszkiewicz, Monika Kowal, Daria Handkiewicz-Junak
Endokrynologia Polska 2010;61(5):486-489.

open access

Vol 61, No 5 (2010)
Review article
Published online: 2010-11-04
Submitted: 2013-02-15

Abstract

Approximately 5% of differentiated thyroid cancers are hereditary. Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]). Among FNMTC, PTC is the most common. Although a hereditary predisposition to non-medullary thyroid cancer is well established, the susceptibility genes are poorly known. Up to now, by linkage analysis using microsatellite markers, several putative loci have been described - 1q21, 6q22, 8p23.1-p22, and 8q24; however, validation studies have been unsuccessful. In the present review we discuss the results of linkage analysis and the most recent results of genome wide association studies (GWAS) with high resolution SNP (single nucleotide polymorphism) arrays.
(Pol J Endocrinol 2010; 61 (5): 486-489)

Abstract

Approximately 5% of differentiated thyroid cancers are hereditary. Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]). Among FNMTC, PTC is the most common. Although a hereditary predisposition to non-medullary thyroid cancer is well established, the susceptibility genes are poorly known. Up to now, by linkage analysis using microsatellite markers, several putative loci have been described - 1q21, 6q22, 8p23.1-p22, and 8q24; however, validation studies have been unsuccessful. In the present review we discuss the results of linkage analysis and the most recent results of genome wide association studies (GWAS) with high resolution SNP (single nucleotide polymorphism) arrays.
(Pol J Endocrinol 2010; 61 (5): 486-489)
Get Citation

Keywords

papillary thyroid carcinoma; familial non-medullary thyroid cancer; genetic predisposition; SNP

About this article
Title

Genetic predisposition to papillary thyroid cancer

Journal

Endokrynologia Polska

Issue

Vol 61, No 5 (2010)

Pages

486-489

Published online

2010-11-04

Bibliographic record

Endokrynologia Polska 2010;61(5):486-489.

Keywords

papillary thyroid carcinoma
familial non-medullary thyroid cancer
genetic predisposition
SNP

Authors

Dorota Kula
Michał Kalemba
Beata Jurecka-Lubieniecka
Zbigniew Puch
Małgorzata Kowalska
Tomasz Tyszkiewicz
Monika Kowal
Daria Handkiewicz-Junak

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