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The role of PET-CT scan with somatostatin analogue labelled with gallium-68 (68Ga-DOTA-TATE PET-CT) in diagnosing patients with disseminated
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Abstract
Introduction: Calcitonin is a very sensitive marker of medullary thyroid carcinoma (MTC). High concentrations of basal or pentagastrin stimulated calcitonin in patients with MTC is a signal of recurrence or metastatic disease. Detection of metastatic foci remains a diagnostic and therapeutic challenge.
The aim of the study was to present examples of the use of 68Ga-DOTA-TATE PET-CT examinations in the diagnosis of patients with MTC and concomitant elevated serum calcitonin concentrations.
Initially the study involved eight patients with MTC and elevated basal or stimulated calcitonin, in which earlier diagnostic imaging was negative for metastasis: neck ultrasound, chest and mediastinal CT scan, liver MRI, bone scintigraphy, and 18F-FDG-PET. A total body scan was performed using 68Ga-DOTA-TATE PET-CT. Two patients with positive diagnostic imaging tests were referred for surgery including resection of cervical lymph nodes with histopathological examination for assessment of metastases.
Conclusions: On the basis of the presented cases we conclude that PET-CT scan with somatostatin analogue labelled with gallium (68Ga-DOTA-TATE PET-CT) may be useful in the diagnostic imaging of patients with disseminated MTC.
(Pol J Endocrinol 2010; 61 (5): 507-511)
Abstract
Introduction: Calcitonin is a very sensitive marker of medullary thyroid carcinoma (MTC). High concentrations of basal or pentagastrin stimulated calcitonin in patients with MTC is a signal of recurrence or metastatic disease. Detection of metastatic foci remains a diagnostic and therapeutic challenge.
The aim of the study was to present examples of the use of 68Ga-DOTA-TATE PET-CT examinations in the diagnosis of patients with MTC and concomitant elevated serum calcitonin concentrations.
Initially the study involved eight patients with MTC and elevated basal or stimulated calcitonin, in which earlier diagnostic imaging was negative for metastasis: neck ultrasound, chest and mediastinal CT scan, liver MRI, bone scintigraphy, and 18F-FDG-PET. A total body scan was performed using 68Ga-DOTA-TATE PET-CT. Two patients with positive diagnostic imaging tests were referred for surgery including resection of cervical lymph nodes with histopathological examination for assessment of metastases.
Conclusions: On the basis of the presented cases we conclude that PET-CT scan with somatostatin analogue labelled with gallium (68Ga-DOTA-TATE PET-CT) may be useful in the diagnostic imaging of patients with disseminated MTC.
(Pol J Endocrinol 2010; 61 (5): 507-511)
Keywords
medullary thyroid carcinoma; 68Ga-DOTA-TATE; positron-emission tomography; calcitonin; neoplasm metastasis
About this articleTitle
The role of PET-CT scan with somatostatin analogue labelled with gallium-68 (68Ga-DOTA-TATE PET-CT) in diagnosing patients with disseminated
Journal
Issue
Article type
Case report
Pages
507-511
Published online
2010-11-04
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736
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1767
Bibliographic record
Endokrynol Pol 2010;61(5):507-511.
Keywords
medullary thyroid carcinoma
68Ga-DOTA-TATE
positron-emission tomography
calcitonin
neoplasm metastasis
Authors
Iwona Pałyga
Aldona Kowalska
Danuta Gąsior-Perczak
Małgorzata Tarnawska-Pierścińska
Janusz Słuszniak
Jacek Sygut
Stanisław Góźdź
