Metabolic memory - the implications for diabetic complications

Ewa Otto-Buczkowska; Łukasz Machnica

Vol 61, No 6 (2010)

Review paper

Submitted: 2013-02-15

Published online: 2010-11-15

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Metabolic memory - the implications for diabetic complications

Ewa Otto-Buczkowska, Łukasz Machnica

Endokrynol Pol 2010;61(6):700-703.

Vol 61, No 6 (2010)

Review Article

Submitted: 2013-02-15

Published online: 2010-11-15

Abstract

Many important biochemical mechanisms are activated in the presence of high levels of glucose, which occur in diabetes. Large randomised studies have established that early intensive glycaemic control reduces the risk of diabetic complications. This phenomenon has recently been dubbed ‘metabolic memory’. It has been suggested that early glycaemia normalisation can halt the hyperglycaemia-induced pathological processes associated with enhanced oxidative stress and glycation of cellular proteins and lipids. The phenomenon of metabolic memory suggests that early aggressive treatment and strict glycaemic control could prevent chronic diabetic complications.
(Pol J Endocrinol 2010; 61 (6): 700-703)