Vol 61, No 6 (2010)
Review paper
Published online: 2010-11-15
Metabolic memory - the implications for diabetic complications
Endokrynol Pol 2010;61(6):700-703.
Abstract
Many important biochemical mechanisms are activated in the presence of high levels of glucose, which occur in diabetes. Large randomised
studies have established that early intensive glycaemic control reduces the risk of diabetic complications. This phenomenon has
recently been dubbed ‘metabolic memory’. It has been suggested that early glycaemia normalisation can halt the hyperglycaemia-induced
pathological processes associated with enhanced oxidative stress and glycation of cellular proteins and lipids. The phenomenon of metabolic
memory suggests that early aggressive treatment and strict glycaemic control could prevent chronic diabetic complications.
(Pol J Endocrinol 2010; 61 (6): 700-703)
(Pol J Endocrinol 2010; 61 (6): 700-703)
Keywords: levels of glucosemetabolic memorydiabetic complications