open access

Vol 61, No 6 (2010)
Review article
Published online: 2010-11-15
Submitted: 2013-02-15
Get Citation

Metabolic memory - the implications for diabetic complications

Ewa Otto-Buczkowska, Łukasz Machnica
Endokrynologia Polska 2010;61(6):700-703.

open access

Vol 61, No 6 (2010)
Review article
Published online: 2010-11-15
Submitted: 2013-02-15

Abstract

Many important biochemical mechanisms are activated in the presence of high levels of glucose, which occur in diabetes. Large randomised studies have established that early intensive glycaemic control reduces the risk of diabetic complications. This phenomenon has recently been dubbed ‘metabolic memory’. It has been suggested that early glycaemia normalisation can halt the hyperglycaemia-induced pathological processes associated with enhanced oxidative stress and glycation of cellular proteins and lipids. The phenomenon of metabolic memory suggests that early aggressive treatment and strict glycaemic control could prevent chronic diabetic complications.
(Pol J Endocrinol 2010; 61 (6): 700-703)

Abstract

Many important biochemical mechanisms are activated in the presence of high levels of glucose, which occur in diabetes. Large randomised studies have established that early intensive glycaemic control reduces the risk of diabetic complications. This phenomenon has recently been dubbed ‘metabolic memory’. It has been suggested that early glycaemia normalisation can halt the hyperglycaemia-induced pathological processes associated with enhanced oxidative stress and glycation of cellular proteins and lipids. The phenomenon of metabolic memory suggests that early aggressive treatment and strict glycaemic control could prevent chronic diabetic complications.
(Pol J Endocrinol 2010; 61 (6): 700-703)
Get Citation

Keywords

levels of glucose; metabolic memory; diabetic complications

About this article
Title

Metabolic memory - the implications for diabetic complications

Journal

Endokrynologia Polska

Issue

Vol 61, No 6 (2010)

Pages

700-703

Published online

2010-11-15

Bibliographic record

Endokrynologia Polska 2010;61(6):700-703.

Keywords

levels of glucose
metabolic memory
diabetic complications

Authors

Ewa Otto-Buczkowska
Łukasz Machnica

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