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Vol 61, No 6 (2010)
Case report
Submitted: 2013-02-15
Published online: 2010-11-15
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An elderly diabetic case of ochronosis with depression and chronic pain

Mehmet Ilkin Naharci, Mehmet Ak, Ergun Bozoglu, Nuri Karadurmus, Ahmet Turan Isik, Huseyin Doruk
Endokrynol Pol 2010;61(6):710-713.

open access

Vol 61, No 6 (2010)
Case report
Submitted: 2013-02-15
Published online: 2010-11-15

Abstract

Alkaptonuria (ochronosis) is a rare autosomal recessive disorder featuring a genetic error in the amino acid metabolism. A defect in the tyrosine metabolism results in the accumulation and deposition of homogentisic acid in connective tissue, causing a blue-black discolouration. Degenerative arthropathy of the spine, knee, and hip are common signs of ochronosis in older age. An association between ochronosis and depression has not previously been discussed in the literature. This case report describes a 69 year-old woman with diabetes mellitus, ochronosis, depression and chronic pain.
(Pol J Endocrinol 2010; 61 (6): 710-713)

Abstract

Alkaptonuria (ochronosis) is a rare autosomal recessive disorder featuring a genetic error in the amino acid metabolism. A defect in the tyrosine metabolism results in the accumulation and deposition of homogentisic acid in connective tissue, causing a blue-black discolouration. Degenerative arthropathy of the spine, knee, and hip are common signs of ochronosis in older age. An association between ochronosis and depression has not previously been discussed in the literature. This case report describes a 69 year-old woman with diabetes mellitus, ochronosis, depression and chronic pain.
(Pol J Endocrinol 2010; 61 (6): 710-713)

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Keywords

alkaptonuria; chronic pain; depression; elderly; ochronosis; diabetes mellitus

About this article
Title

An elderly diabetic case of ochronosis with depression and chronic pain

Journal

Endokrynologia Polska

Issue

Vol 61, No 6 (2010)

Article type

Case report

Pages

710-713

Published online

2010-11-15

Page views

623

Article views/downloads

1172

Bibliographic record

Endokrynol Pol 2010;61(6):710-713.

Keywords

alkaptonuria
chronic pain
depression
elderly
ochronosis
diabetes mellitus

Authors

Mehmet Ilkin Naharci
Mehmet Ak
Ergun Bozoglu
Nuri Karadurmus
Ahmet Turan Isik
Huseyin Doruk

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