Vol 61, No 6 (2010)
Case report
Published online: 2010-11-15

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An elderly diabetic case of ochronosis with depression and chronic pain

Mehmet Ilkin Naharci, Mehmet Ak, Ergun Bozoglu, Nuri Karadurmus, Ahmet Turan Isik, Huseyin Doruk
Endokrynol Pol 2010;61(6):710-713.


Alkaptonuria (ochronosis) is a rare autosomal recessive disorder featuring a genetic error in the amino acid metabolism. A defect in the tyrosine metabolism results in the accumulation and deposition of homogentisic acid in connective tissue, causing a blue-black discolouration. Degenerative arthropathy of the spine, knee, and hip are common signs of ochronosis in older age. An association between ochronosis and depression has not previously been discussed in the literature. This case report describes a 69 year-old woman with diabetes mellitus, ochronosis, depression and chronic pain.
(Pol J Endocrinol 2010; 61 (6): 710-713)

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