open access

Vol 61, No 6 (2010)
Original papers
Published online: 2010-11-15
Submitted: 2013-02-15
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Transforming growth factor β (TGF-β) levels in otherwise healthy subjects with impaired glucose tolerance

Halil Genc, Nuri Karadurmus, Ucler Kisa, Serkan Tapan, Ilkin Naharci, Alper Sonmez, Teoman Dogru
Endokrynologia Polska 2010;61(6):691-694.

open access

Vol 61, No 6 (2010)
Original papers
Published online: 2010-11-15
Submitted: 2013-02-15

Abstract


Introduction: Serum transforming growth factor beta (TGF-β) level is increased in type-2 diabetes mellitus (T2DM) and certain diabetic complications are mediated by this cytokine. Impaired glucose tolerance (IGT) is a prediabetic condition, and confers a risk for the development of certain diabetes-specific complications. However, no data is available regarding the alteration of TGF-β in IGT subjects. Therefore, we aimed to investigate TGF-β levels in otherwise healthy subjects with IGT.
Material and methods: Thirty IGT subjects and 30 subjects relatively matched for age, sex and body mass index with normal glucose tolerance were enrolled. Subjects with overt diabetes, cardiovascular, renal or inflammatory disease, or on any medication were excluded. Relevant laboratory examinations were performed by routine methods. Assessment of TGF-β was made by a commercially available enzyme-linked immunosorbent assay kit. IGT and control subjects were compared for their clinical and laboratory parameters.
Results: Serum TGF-&#946; levels were found to be similar in IGT and normal glucose tolerance subjects (p < 0.05). No statistically significant correlation was found between TGF-&#946; and other laboratory parameters, either in IGT subjects or in the whole study population.
Conclusions: Serum TGF-&#946; is not elevated in otherwise healthy subjects with IGT. The results of our study imply that the presence of IGT alone is not sufficient to induce TGF-&#946; elevation; and for the alteration of TGF-&#946;, worsening of metabolic risk factors may be required.
(Pol J Endocrinol 2010; 61 (6): 691-694)

Abstract


Introduction: Serum transforming growth factor beta (TGF-&#946;) level is increased in type-2 diabetes mellitus (T2DM) and certain diabetic complications are mediated by this cytokine. Impaired glucose tolerance (IGT) is a prediabetic condition, and confers a risk for the development of certain diabetes-specific complications. However, no data is available regarding the alteration of TGF-&#946; in IGT subjects. Therefore, we aimed to investigate TGF-&#946; levels in otherwise healthy subjects with IGT.
Material and methods: Thirty IGT subjects and 30 subjects relatively matched for age, sex and body mass index with normal glucose tolerance were enrolled. Subjects with overt diabetes, cardiovascular, renal or inflammatory disease, or on any medication were excluded. Relevant laboratory examinations were performed by routine methods. Assessment of TGF-&#946; was made by a commercially available enzyme-linked immunosorbent assay kit. IGT and control subjects were compared for their clinical and laboratory parameters.
Results: Serum TGF-&#946; levels were found to be similar in IGT and normal glucose tolerance subjects (p < 0.05). No statistically significant correlation was found between TGF-&#946; and other laboratory parameters, either in IGT subjects or in the whole study population.
Conclusions: Serum TGF-&#946; is not elevated in otherwise healthy subjects with IGT. The results of our study imply that the presence of IGT alone is not sufficient to induce TGF-&#946; elevation; and for the alteration of TGF-&#946;, worsening of metabolic risk factors may be required.
(Pol J Endocrinol 2010; 61 (6): 691-694)
Get Citation

Keywords

TGF-β; impaired glucose tolerance; cytokine

About this article
Title

Transforming growth factor β (TGF-β) levels in otherwise healthy subjects with impaired glucose tolerance

Journal

Endokrynologia Polska

Issue

Vol 61, No 6 (2010)

Pages

691-694

Published online

2010-11-15

Bibliographic record

Endokrynologia Polska 2010;61(6):691-694.

Keywords

TGF-β
impaired glucose tolerance
cytokine

Authors

Halil Genc
Nuri Karadurmus
Ucler Kisa
Serkan Tapan
Ilkin Naharci
Alper Sonmez
Teoman Dogru

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