open access

Vol 61, No 6 (2010)
Original papers
Published online: 2010-11-15
Submitted: 2013-02-15
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Sonographic assessment of congenitally hypothyroid children in Iran

Mohsen Hoseini, Ali Hekmatnia, Mahin Hashemipour, Reza Basiratnia, Navid Omidifar, Afshin Rezazade, Razie Koohi
Endokrynologia Polska 2010;61(6):665-670.

open access

Vol 61, No 6 (2010)
Original papers
Published online: 2010-11-15
Submitted: 2013-02-15

Abstract


Introduction: Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, it seems that it is necessary to investigate the aetiology of the disorder and its related factors. The aim of this study was to determine the aetiology of CH among children in Isfahan province.
Material and methods: In this cross-sectional study, the aetiology of CH and the volume of the thyroid was assessed using neck ultrasonography. The results of thyroid function screening tests were additionally recorded. The correlation between ultrasonographic findings and the level of TSH and as well as T4 was determined.
Results: During this study 385 CH patients aged 0-3 years were studied. According to ultrasonographic findings, in 19.9% of patients the aetiology of CH was dysgenesis (agenesis, ectopy, and hemiagenesis) and 80.1% had normal thyroid. Mean thyroid gland volume in all studied patients was 0.78 &#177; 0.44 mL. The prevalence of ultrasonographic findings was as follows: normal 80.1%, agenesis 12.7%, hemiagenesis 5.8%, and ectopy 1.4%. There was a significant correlation between thyroid volume and TSH and T4 and as well as between TSH and ultrasonographic findings (p < 0.05).
Conclusions: In spite of the limitations of ultrasonography in the field of determining the aetiology of CH, it is an appropriate imaging tool for determining the volume of the thyroid gland in children. Considering that the rate of goitrous gland was low, it seems that iodine deficiency could not be responsible for the high rate of CH in this region.
(Pol J Endocrinol 2010; 61 (6): 665-670)

Abstract


Introduction: Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, it seems that it is necessary to investigate the aetiology of the disorder and its related factors. The aim of this study was to determine the aetiology of CH among children in Isfahan province.
Material and methods: In this cross-sectional study, the aetiology of CH and the volume of the thyroid was assessed using neck ultrasonography. The results of thyroid function screening tests were additionally recorded. The correlation between ultrasonographic findings and the level of TSH and as well as T4 was determined.
Results: During this study 385 CH patients aged 0-3 years were studied. According to ultrasonographic findings, in 19.9% of patients the aetiology of CH was dysgenesis (agenesis, ectopy, and hemiagenesis) and 80.1% had normal thyroid. Mean thyroid gland volume in all studied patients was 0.78 &#177; 0.44 mL. The prevalence of ultrasonographic findings was as follows: normal 80.1%, agenesis 12.7%, hemiagenesis 5.8%, and ectopy 1.4%. There was a significant correlation between thyroid volume and TSH and T4 and as well as between TSH and ultrasonographic findings (p < 0.05).
Conclusions: In spite of the limitations of ultrasonography in the field of determining the aetiology of CH, it is an appropriate imaging tool for determining the volume of the thyroid gland in children. Considering that the rate of goitrous gland was low, it seems that iodine deficiency could not be responsible for the high rate of CH in this region.
(Pol J Endocrinol 2010; 61 (6): 665-670)
Get Citation

Keywords

congenital hypothyroidism; thyroid volume; ultrasonography

About this article
Title

Sonographic assessment of congenitally hypothyroid children in Iran

Journal

Endokrynologia Polska

Issue

Vol 61, No 6 (2010)

Pages

665-670

Published online

2010-11-15

Bibliographic record

Endokrynologia Polska 2010;61(6):665-670.

Keywords

congenital hypothyroidism
thyroid volume
ultrasonography

Authors

Mohsen Hoseini
Ali Hekmatnia
Mahin Hashemipour
Reza Basiratnia
Navid Omidifar
Afshin Rezazade
Razie Koohi

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