open access

Vol 61, No 6 (2010)
Original papers
Published online: 2010-11-15
Submitted: 2013-02-15
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Real-time ultrasound elastography - a new tool for diagnosing thyroid nodules

Małgorzata Gietka-Czernel, Magdalena Kochman, Karolina Bujalska, Elżbieta Stachlewska-Nasfeter, Wojciech Zgliczyński
Endokrynologia Polska 2010;61(6):652-657.

open access

Vol 61, No 6 (2010)
Original papers
Published online: 2010-11-15
Submitted: 2013-02-15

Abstract


Introduction: Real-time elastography (RTE) is a non-invasive ultrasound method of estimation of tissue stiffness by measuring the degree of local tissue displacements after a small compression. Recent data has shown its ability to differentiate benign from malignant tumours. The aim of this study was to evaluate the accuracy of RTE in the diagnosis of malignant and benign thyroid nodules.
Material and methods: 71 thyroid nodules in 52 patients: 42 females and 10 males aged 28-77 were examined using conventional ultrasonography (US), fine-flow CD imaging and RTE. All nodules previously underwent fine-needle aspiration biopsy (FNAB), and patients with malignant and suspicious cytological results were referred for surgery. The final diagnosis was based on FNAB results in patients with benign cytology and on the histopathology reading in those who underwent surgery. An elasticity score (ES) from 1 to 5 was determined for each nodule according to the Ueno classification.
Results: An elasticity score (ES) of 4 or 5 was found in 19 out of 22 (86.5%) thyroid cancers and in only 1 out of 31 (3%) benign nodules. This was strongly indicative for malignancy (p < 0.0001) with sensitivity 86%, specificity 97%, positive predictive value (PPV) 95% and negative predictive value (NPV) 91%.
Conclusions: RTE is a highly sensitive and specific method of diagnosing thyroid nodules. This technique can be employed in selecting thyroid nodules for fine-needle aspiration biopsy.
(Pol J Endocrinol 2010; 61 (6): 652-657)

Abstract


Introduction: Real-time elastography (RTE) is a non-invasive ultrasound method of estimation of tissue stiffness by measuring the degree of local tissue displacements after a small compression. Recent data has shown its ability to differentiate benign from malignant tumours. The aim of this study was to evaluate the accuracy of RTE in the diagnosis of malignant and benign thyroid nodules.
Material and methods: 71 thyroid nodules in 52 patients: 42 females and 10 males aged 28-77 were examined using conventional ultrasonography (US), fine-flow CD imaging and RTE. All nodules previously underwent fine-needle aspiration biopsy (FNAB), and patients with malignant and suspicious cytological results were referred for surgery. The final diagnosis was based on FNAB results in patients with benign cytology and on the histopathology reading in those who underwent surgery. An elasticity score (ES) from 1 to 5 was determined for each nodule according to the Ueno classification.
Results: An elasticity score (ES) of 4 or 5 was found in 19 out of 22 (86.5%) thyroid cancers and in only 1 out of 31 (3%) benign nodules. This was strongly indicative for malignancy (p < 0.0001) with sensitivity 86%, specificity 97%, positive predictive value (PPV) 95% and negative predictive value (NPV) 91%.
Conclusions: RTE is a highly sensitive and specific method of diagnosing thyroid nodules. This technique can be employed in selecting thyroid nodules for fine-needle aspiration biopsy.
(Pol J Endocrinol 2010; 61 (6): 652-657)
Get Citation

Keywords

thyroid nodule; elastography; ultrasonography

About this article
Title

Real-time ultrasound elastography - a new tool for diagnosing thyroid nodules

Journal

Endokrynologia Polska

Issue

Vol 61, No 6 (2010)

Pages

652-657

Published online

2010-11-15

Bibliographic record

Endokrynologia Polska 2010;61(6):652-657.

Keywords

thyroid nodule
elastography
ultrasonography

Authors

Małgorzata Gietka-Czernel
Magdalena Kochman
Karolina Bujalska
Elżbieta Stachlewska-Nasfeter
Wojciech Zgliczyński

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