open access

Vol 62, No 1 (2011)
Review article
Published online: 2011-03-01
Submitted: 2013-02-15
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Strontium ranelate in post-menopausal osteoporosis

Jerzy Przedlacki
Endokrynologia Polska 2011;62(1):65-72.

open access

Vol 62, No 1 (2011)
Review article
Published online: 2011-03-01
Submitted: 2013-02-15

Abstract

Strontium ranelate is one of the first-line agents with proven anti-fracture activity used in the therapy of post-menopausal osteoporosis. Its mechanism of action makes it, however, different from other drugs, since it simultaneously stimulates two reverse processes: bone formation and bone resorption. The action of the agent depends on various mechanisms, including the activation of calcium receptors, localised on osteoblasts and osteoclasts, and on the influence on the OPG/RANKL system. The drug effectively prevents spinal, hip and extravertebral fractures. The agent’s anti-fracture efficacy within the spine does not depend on the patient’s age, or on base BMD values, or on the concentration of bone metabolism markers. As to the anti-fracture efficacy in the hip, it concerns women with an increased bone fracture risk. Strontium ranelate increases bone mineral density within the lumbar spine and the hip, decreases the concentrations of bone resorption markers, and increases the concentrations of bone formation markers. The drug is administered in a daily 2.0 g oral dose.
This paper presents indications to therapy with strontium ranelate, specifying also its side effects and contraindications. We compare the anti-fracture efficacy of strontium ranelate to the efficacy of other agents of proven anti-fracture activity, based on published clinical studies. (Pol J Endocrinol 2011; 62 (1): 65-72)

Abstract

Strontium ranelate is one of the first-line agents with proven anti-fracture activity used in the therapy of post-menopausal osteoporosis. Its mechanism of action makes it, however, different from other drugs, since it simultaneously stimulates two reverse processes: bone formation and bone resorption. The action of the agent depends on various mechanisms, including the activation of calcium receptors, localised on osteoblasts and osteoclasts, and on the influence on the OPG/RANKL system. The drug effectively prevents spinal, hip and extravertebral fractures. The agent’s anti-fracture efficacy within the spine does not depend on the patient’s age, or on base BMD values, or on the concentration of bone metabolism markers. As to the anti-fracture efficacy in the hip, it concerns women with an increased bone fracture risk. Strontium ranelate increases bone mineral density within the lumbar spine and the hip, decreases the concentrations of bone resorption markers, and increases the concentrations of bone formation markers. The drug is administered in a daily 2.0 g oral dose.
This paper presents indications to therapy with strontium ranelate, specifying also its side effects and contraindications. We compare the anti-fracture efficacy of strontium ranelate to the efficacy of other agents of proven anti-fracture activity, based on published clinical studies. (Pol J Endocrinol 2011; 62 (1): 65-72)
Get Citation

Keywords

treatment; osteoporosis; strontium ranelate

About this article
Title

Strontium ranelate in post-menopausal osteoporosis

Journal

Endokrynologia Polska

Issue

Vol 62, No 1 (2011)

Pages

65-72

Published online

2011-03-01

Bibliographic record

Endokrynologia Polska 2011;62(1):65-72.

Keywords

treatment
osteoporosis
strontium ranelate

Authors

Jerzy Przedlacki

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