Vol 62, No 1 (2011)
Review paper
Submitted: 2013-02-15
Published online: 2011-03-01
The role of hormonal therapy in osteoporosis
Wanda Horst-Sikorska, Anna Wawrzyniak
Endokrynol Pol 2011;62(1):61-64.
Vol 62, No 1 (2011)
Review Article
Submitted: 2013-02-15
Published online: 2011-03-01
Abstract
In developed societies, the post-menopausal period covers approximately one third of a woman’s life. The deficit of oestrogens observed
during the post-menopausal period significantly affects the course of many metabolic processes, causing a number of diseases and in
consequence diminishing quality of life. Among others, bones belong to oestrogen-dependent tissues. The deficit of the protective influence
of oestrogens compromises the dynamic balance of the bone transformation process towards resorption, thus reducing bone mass
and quality, while increasing the risk of low-energy fractures. In recent years, differing views on the application of oestrogen/gestagen
therapy have reached the level of controversy. The results of numerous clinical studies are far from unequivocal, with the whole subject
one of heated debate. It has been confirmed that hormonal therapy prevents bone quality deterioration, while opening a protective
umbrella around the bone, reducing the risk of osteoporotic fractures. A rational approach to weighing possible advantages against possible
risks and a thorough evaluation of a patient’s health condition allows for optimal therapy selection.
(Pol J Endocrinol 2011; 62 (1): 61-64)
Abstract
In developed societies, the post-menopausal period covers approximately one third of a woman’s life. The deficit of oestrogens observed
during the post-menopausal period significantly affects the course of many metabolic processes, causing a number of diseases and in
consequence diminishing quality of life. Among others, bones belong to oestrogen-dependent tissues. The deficit of the protective influence
of oestrogens compromises the dynamic balance of the bone transformation process towards resorption, thus reducing bone mass
and quality, while increasing the risk of low-energy fractures. In recent years, differing views on the application of oestrogen/gestagen
therapy have reached the level of controversy. The results of numerous clinical studies are far from unequivocal, with the whole subject
one of heated debate. It has been confirmed that hormonal therapy prevents bone quality deterioration, while opening a protective
umbrella around the bone, reducing the risk of osteoporotic fractures. A rational approach to weighing possible advantages against possible
risks and a thorough evaluation of a patient’s health condition allows for optimal therapy selection.
(Pol J Endocrinol 2011; 62 (1): 61-64)
Keywords
osteoporosis; hormone replacement therapy; benefits; risk factors
Title
The role of hormonal therapy in osteoporosis
Journal
Endokrynologia Polska
Issue
Vol 62, No 1 (2011)
Article type
Review paper
Pages
61-64
Published online
2011-03-01
Page views
559
Article views/downloads
919
Bibliographic record
Endokrynol Pol 2011;62(1):61-64.
Keywords
osteoporosis
hormone replacement therapy
benefits
risk factors
Authors
Wanda Horst-Sikorska
Anna Wawrzyniak
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