open access

Vol 62, No 1 (2011)
Original papers
Published online: 2011-03-01
Submitted: 2013-02-15
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A discussion of the intervention thresholds in osteoporosis treatment in Poland

Michalina Marcinkowska, Magdalena Ignaszak-Szczepaniak, Anna Wawrzyniak, Joanna Dytfeld, Wanda Horst-Sikorska
Endokrynologia Polska 2011;62(1):30-36.

open access

Vol 62, No 1 (2011)
Original papers
Published online: 2011-03-01
Submitted: 2013-02-15

Abstract


Introduction: Epidemiological prognoses regarding the global spread of post-menopausal osteoporosis can prove somewhat nebulous. But it is clear that low-energy fractures and their consequences will become an increasingly serious health problem. Therefore it is crucial to implement prognostic procedures which could more effectively predict the incidence of osteoporosis and its complications.
Material and methods: The study involved 378 female patients aged 40–86 years for whom clinical risk factors of osteoporotic fracture were analysed. Densitometry (DPX) was performed at femoral neck. The 10–year risk of fracture was assessed according to the British model of FRAX calculator.
Results: The study group was divided into two, depending on the history of low-energy fractures. Previous osteoporotic fractures were confirmed in 128 patients. In this group, the mean bone mineral density (BMD) values (0.717 g/cm2) were lower than in the group without fracture history (0.735 g/cm2). In 33.3% of patients aged 50-59 years and 17% of women aged 60-79 who required medical treatment for their clinical status (previous fracture), the FRAX value did not meet the criterion of pharmacotherapy administration. Considering BMD in the calculation of FRAX produced an even higher underestimation of the fracture risk. Of women aged 40-49, 25% were qualified for pharmacotherapy of osteoporosis. In that particular age category, BMD did not affect the FRAX value. BMD measurement had a higher discriminatory value among patients aged 50-79, increasing the number of patients requiring therapy by more than 50%.
Conclusions:
1. The FRAX calculator does not always consider the history of low-energy fractures as a criterion sufficient for therapy implementation.
2. Designing a FRAX calculator specifically for the Polish population would be advisable. (Pol J Endocrinol 2011; 62 (1): 30-36)

Abstract


Introduction: Epidemiological prognoses regarding the global spread of post-menopausal osteoporosis can prove somewhat nebulous. But it is clear that low-energy fractures and their consequences will become an increasingly serious health problem. Therefore it is crucial to implement prognostic procedures which could more effectively predict the incidence of osteoporosis and its complications.
Material and methods: The study involved 378 female patients aged 40–86 years for whom clinical risk factors of osteoporotic fracture were analysed. Densitometry (DPX) was performed at femoral neck. The 10–year risk of fracture was assessed according to the British model of FRAX calculator.
Results: The study group was divided into two, depending on the history of low-energy fractures. Previous osteoporotic fractures were confirmed in 128 patients. In this group, the mean bone mineral density (BMD) values (0.717 g/cm2) were lower than in the group without fracture history (0.735 g/cm2). In 33.3% of patients aged 50-59 years and 17% of women aged 60-79 who required medical treatment for their clinical status (previous fracture), the FRAX value did not meet the criterion of pharmacotherapy administration. Considering BMD in the calculation of FRAX produced an even higher underestimation of the fracture risk. Of women aged 40-49, 25% were qualified for pharmacotherapy of osteoporosis. In that particular age category, BMD did not affect the FRAX value. BMD measurement had a higher discriminatory value among patients aged 50-79, increasing the number of patients requiring therapy by more than 50%.
Conclusions:
1. The FRAX calculator does not always consider the history of low-energy fractures as a criterion sufficient for therapy implementation.
2. Designing a FRAX calculator specifically for the Polish population would be advisable. (Pol J Endocrinol 2011; 62 (1): 30-36)
Get Citation

Keywords

osteoporosis treatment; FRAX calculator; intervention thersholds

About this article
Title

A discussion of the intervention thresholds in osteoporosis treatment in Poland

Journal

Endokrynologia Polska

Issue

Vol 62, No 1 (2011)

Pages

30-36

Published online

2011-03-01

Bibliographic record

Endokrynologia Polska 2011;62(1):30-36.

Keywords

osteoporosis treatment
FRAX calculator
intervention thersholds

Authors

Michalina Marcinkowska
Magdalena Ignaszak-Szczepaniak
Anna Wawrzyniak
Joanna Dytfeld
Wanda Horst-Sikorska

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