Vol 62, No 2 (2011)
Review paper
Published online: 2011-04-29
Diabetic pulmonary microangiopathy — fact or fiction?
Endokrynol Pol 2011;62(2):171-176.
Abstract
Elevated levels of serum glucose have deleterious effects on the walls of blood vessels, leading to microangiopathy. Such a destructive
process involves also pulmonary circulation, where it is referred to as diabetic pulmonary microangiopathy. This hypothesis has been
confirmed in histopathologic examinations of pulmonary parenchyma, as well as in pulmonary function tests. However, so far there have
been no clinical implications of these findings.
Another phenomenon requiring further discussion involves diabetics with clinically silent respiratory dysfunction. That may result from significant vascular and ventilation reserves that compensate for partial loss of pulmonary parenchyma in the course of diabetes. In this review, we present an overview of the available publications on pulmonary microangiopathy and its influence on the functioning of the respiratory system. (Pol J Endocrinol 2011; 62 (2): 171–175)
Another phenomenon requiring further discussion involves diabetics with clinically silent respiratory dysfunction. That may result from significant vascular and ventilation reserves that compensate for partial loss of pulmonary parenchyma in the course of diabetes. In this review, we present an overview of the available publications on pulmonary microangiopathy and its influence on the functioning of the respiratory system. (Pol J Endocrinol 2011; 62 (2): 171–175)
Keywords: diabetes mellituslung microangiopathypulmonary function testslung diffusing capacity for carbon monoxide