open access

Vol 62, No 2 (2011)
Original papers
Published online: 2011-04-29
Submitted: 2013-02-15
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Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS)

Agnieszka Lenarcik, Bożena Bidzińska-Speichert, Urszula Tworowska-Bardzińska, Katarzyna Krępuła
Endokrynologia Polska 2011;62(2):129-133.

open access

Vol 62, No 2 (2011)
Original papers
Published online: 2011-04-29
Submitted: 2013-02-15

Abstract

Introduction: A body of evidence points to a familial aggregation of hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS). The aim of this study was to determine whether siblings of women with PCOS had evidence of hormonal abnormalities typical of PCOS.
Material and methods: Eighty-six siblings of women with PCOS (44 sisters, 42 brothers) were recruited. Two control groups consisted of 70 healthy women and 30 healthy men. Anthropometric, hormonal (testosterone, androstenedione, DHEA-S, LH, FSH) parameters and SHBG were assessed in all subjects.
Results: Mean testosterone and DHEA-S levels were higher in sisters of women with PCOS than in the control women. In eight of the 44 (18.2%) sisters, a diagnosis of PCOS was made. Mean testosterone and androstenedione levels, and free androgen index (FAI) were significantly higher in sisters with PCOS compared to the sisters without PCOS. Brothers of women with PCOS had higher DHEA-S level than the control men. Eleven of the 42 (26.2%) brothers had alopecia occurring before the age of 30. Prematurely balding brothers did not differ from the non-balding brothers in hormonal parameters.
Conclusions: Siblings of women with PCOS are predisposed to hormonal abnormalities typical of PCOS. The symptom of premature balding under the age of 30 in brothers of women with PCOS should not be considered as a male PCOS equivalent.
(Pol J Endocrinol 2011; 62 (2): 129–133)

Abstract

Introduction: A body of evidence points to a familial aggregation of hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS). The aim of this study was to determine whether siblings of women with PCOS had evidence of hormonal abnormalities typical of PCOS.
Material and methods: Eighty-six siblings of women with PCOS (44 sisters, 42 brothers) were recruited. Two control groups consisted of 70 healthy women and 30 healthy men. Anthropometric, hormonal (testosterone, androstenedione, DHEA-S, LH, FSH) parameters and SHBG were assessed in all subjects.
Results: Mean testosterone and DHEA-S levels were higher in sisters of women with PCOS than in the control women. In eight of the 44 (18.2%) sisters, a diagnosis of PCOS was made. Mean testosterone and androstenedione levels, and free androgen index (FAI) were significantly higher in sisters with PCOS compared to the sisters without PCOS. Brothers of women with PCOS had higher DHEA-S level than the control men. Eleven of the 42 (26.2%) brothers had alopecia occurring before the age of 30. Prematurely balding brothers did not differ from the non-balding brothers in hormonal parameters.
Conclusions: Siblings of women with PCOS are predisposed to hormonal abnormalities typical of PCOS. The symptom of premature balding under the age of 30 in brothers of women with PCOS should not be considered as a male PCOS equivalent.
(Pol J Endocrinol 2011; 62 (2): 129–133)
Get Citation

Keywords

polycystic ovary syndrome (PCOS); siblings; familial occurrence; hormonal disturbances

About this article
Title

Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS)

Journal

Endokrynologia Polska

Issue

Vol 62, No 2 (2011)

Pages

129-133

Published online

2011-04-29

Bibliographic record

Endokrynologia Polska 2011;62(2):129-133.

Keywords

polycystic ovary syndrome (PCOS)
siblings
familial occurrence
hormonal disturbances

Authors

Agnieszka Lenarcik
Bożena Bidzińska-Speichert
Urszula Tworowska-Bardzińska
Katarzyna Krępuła

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