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Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS)
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Abstract
Material and methods: Eighty-six siblings of women with PCOS (44 sisters, 42 brothers) were recruited. Two control groups consisted of 70 healthy women and 30 healthy men. Anthropometric, hormonal (testosterone, androstenedione, DHEA-S, LH, FSH) parameters and SHBG were assessed in all subjects.
Results: Mean testosterone and DHEA-S levels were higher in sisters of women with PCOS than in the control women. In eight of the 44 (18.2%) sisters, a diagnosis of PCOS was made. Mean testosterone and androstenedione levels, and free androgen index (FAI) were significantly higher in sisters with PCOS compared to the sisters without PCOS. Brothers of women with PCOS had higher DHEA-S level than the control men. Eleven of the 42 (26.2%) brothers had alopecia occurring before the age of 30. Prematurely balding brothers did not differ from the non-balding brothers in hormonal parameters.
Conclusions: Siblings of women with PCOS are predisposed to hormonal abnormalities typical of PCOS. The symptom of premature balding under the age of 30 in brothers of women with PCOS should not be considered as a male PCOS equivalent.
(Pol J Endocrinol 2011; 62 (2): 129–133)
Abstract
Material and methods: Eighty-six siblings of women with PCOS (44 sisters, 42 brothers) were recruited. Two control groups consisted of 70 healthy women and 30 healthy men. Anthropometric, hormonal (testosterone, androstenedione, DHEA-S, LH, FSH) parameters and SHBG were assessed in all subjects.
Results: Mean testosterone and DHEA-S levels were higher in sisters of women with PCOS than in the control women. In eight of the 44 (18.2%) sisters, a diagnosis of PCOS was made. Mean testosterone and androstenedione levels, and free androgen index (FAI) were significantly higher in sisters with PCOS compared to the sisters without PCOS. Brothers of women with PCOS had higher DHEA-S level than the control men. Eleven of the 42 (26.2%) brothers had alopecia occurring before the age of 30. Prematurely balding brothers did not differ from the non-balding brothers in hormonal parameters.
Conclusions: Siblings of women with PCOS are predisposed to hormonal abnormalities typical of PCOS. The symptom of premature balding under the age of 30 in brothers of women with PCOS should not be considered as a male PCOS equivalent.
(Pol J Endocrinol 2011; 62 (2): 129–133)
Keywords
polycystic ovary syndrome (PCOS); siblings; familial occurrence; hormonal disturbances
About this articleTitle
Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS)
Journal
Issue
Article type
Original paper
Pages
129-133
Published online
2011-04-29
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756
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2158
Bibliographic record
Endokrynol Pol 2011;62(2):129-133.
Keywords
polycystic ovary syndrome (PCOS)
siblings
familial occurrence
hormonal disturbances
Authors
Agnieszka Lenarcik
Bożena Bidzińska-Speichert
Urszula Tworowska-Bardzińska
Katarzyna Krępuła
