open access

Vol 62, No 2 (2011)
Original papers
Published online: 2011-04-29
Submitted: 2013-02-15
Get Citation

Are metabolic syndrome and its components in obese children influenced by the overweight status or the insulin resistance?

Agnieszka Zachurzok-Buczyńska, Katarzyna Klimek, Małgorzata Firek-Pedras, Ewa Małecka-Tendera
Endokrynologia Polska 2011;62(2):102-108.

open access

Vol 62, No 2 (2011)
Original papers
Published online: 2011-04-29
Submitted: 2013-02-15

Abstract

Introduction: The aim of this study was to determine which factors increase the risk of metabolic syndrome (MS) and its components in obese children and adolescents.
Material and methods: In 78 obese children (42 girls, 36 boys), mean age 14.6 ± 3.5 years, blood pressure, total cholesterol, triglycerides, HDL-cholesterol (HDL), insulin and glucose at fasting state as well as in OGTT were measured. Body mass index (BMI) Z-score, LDLcholesterol, and insulin resistance indices (FIGR, R-HOMA) were calculated.
Results: Metabolic syndrome was diagnosed in ten (12.8%) children. Hyperinsulinaemia was present in 42 (53.8%) subjects, increased FIGR in eight (10.3%) and increased R-HOMA in 49 (62.3%). Significant correlations between BMI Z-score ≥ 2.5 and MS occurrence and its components (hypertriglyceridaemia, isolated systolic and diastolic hypertension) were found. Hypertriglyceridaemia, low HDL and hypertension, as well as MS occurrence, correlated significantly with stimulated hyperinsulinaemia and increased FIGR. Risk of hypertension was increased 5.6 times by fasting hyperinsulinaemia. Stimulated hyperinsulinaemia increased the risk of hypertriglyceridaemia 3.7 times, risk of low HDL 14.4 times and risk of MS 10.3 times. These risks did not change significantly when adjusted for BMI Z-score.
Conclusions: Our study results show that both BMI Z-score and OGTT stimulated hyperinsulinaemia are good predictors of MS occurrence in obese children and adolescents. The risk of dyslipidaemia and hypertension increase significantly with hyperinsulinaemia and insulin resistance, with low HDL cholesterol being the most affected. (Pol J Endocrinol 2011; 62 (2): 102–108)

Abstract

Introduction: The aim of this study was to determine which factors increase the risk of metabolic syndrome (MS) and its components in obese children and adolescents.
Material and methods: In 78 obese children (42 girls, 36 boys), mean age 14.6 ± 3.5 years, blood pressure, total cholesterol, triglycerides, HDL-cholesterol (HDL), insulin and glucose at fasting state as well as in OGTT were measured. Body mass index (BMI) Z-score, LDLcholesterol, and insulin resistance indices (FIGR, R-HOMA) were calculated.
Results: Metabolic syndrome was diagnosed in ten (12.8%) children. Hyperinsulinaemia was present in 42 (53.8%) subjects, increased FIGR in eight (10.3%) and increased R-HOMA in 49 (62.3%). Significant correlations between BMI Z-score ≥ 2.5 and MS occurrence and its components (hypertriglyceridaemia, isolated systolic and diastolic hypertension) were found. Hypertriglyceridaemia, low HDL and hypertension, as well as MS occurrence, correlated significantly with stimulated hyperinsulinaemia and increased FIGR. Risk of hypertension was increased 5.6 times by fasting hyperinsulinaemia. Stimulated hyperinsulinaemia increased the risk of hypertriglyceridaemia 3.7 times, risk of low HDL 14.4 times and risk of MS 10.3 times. These risks did not change significantly when adjusted for BMI Z-score.
Conclusions: Our study results show that both BMI Z-score and OGTT stimulated hyperinsulinaemia are good predictors of MS occurrence in obese children and adolescents. The risk of dyslipidaemia and hypertension increase significantly with hyperinsulinaemia and insulin resistance, with low HDL cholesterol being the most affected. (Pol J Endocrinol 2011; 62 (2): 102–108)
Get Citation

Keywords

insulin resistance; hyperinsulinaemia; metabolic syndrome; children; adolescents

About this article
Title

Are metabolic syndrome and its components in obese children influenced by the overweight status or the insulin resistance?

Journal

Endokrynologia Polska

Issue

Vol 62, No 2 (2011)

Pages

102-108

Published online

2011-04-29

Bibliographic record

Endokrynologia Polska 2011;62(2):102-108.

Keywords

insulin resistance
hyperinsulinaemia
metabolic syndrome
children
adolescents

Authors

Agnieszka Zachurzok-Buczyńska
Katarzyna Klimek
Małgorzata Firek-Pedras
Ewa Małecka-Tendera

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl