Vol 62, No 3 (2011)
Case report
Published online: 2011-06-29
Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing’s disease resistant to surgery
Endokrynol Pol 2011;62(3):271-274.
Abstract
Without treatment, Cushing’s disease has significant morbidity and mortality. Where a surgical approach may not be feasible, or is refused
by the patient, medical therapy becomes the only option. In this case report, we discuss the effects of two years of ketoconazole treatment
on diabetes regulation and insulin resistance in a patient reluctant to agree to surgery. A 62 year-old female patient with uncontrolled type
2 diabetes mellitus was investigated. Cushing’s disease was confirmed by the results of high urine free cortisol level and dexamethasone
suppression tests.
We discuss the effects of two years of 600 mg/day ketoconazole treatment on diabetes regulation and insulin resistance in a patient with Cushing’s disease reluctant to agree to surgery. This case report illustrates the beneficial long-term effects of 24 months of ketoconazole treatment on the clinical and laboratory findings and also on steroid and glucose metabolism. (Pol J Endocrinol 2011; 62 (3): 271–274)
We discuss the effects of two years of 600 mg/day ketoconazole treatment on diabetes regulation and insulin resistance in a patient with Cushing’s disease reluctant to agree to surgery. This case report illustrates the beneficial long-term effects of 24 months of ketoconazole treatment on the clinical and laboratory findings and also on steroid and glucose metabolism. (Pol J Endocrinol 2011; 62 (3): 271–274)
Keywords: Cushing’s diseaseketoconazoleinsulin resistanceHOMA
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