open access

Vol 62, No 3 (2011)
Case report
Published online: 2011-06-29
Submitted: 2013-02-15
Get Citation

Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing’s disease resistant to surgery

Meral Mert, Gonenc Kocabay
Endokrynologia Polska 2011;62(3):271-274.

open access

Vol 62, No 3 (2011)
Case report
Published online: 2011-06-29
Submitted: 2013-02-15

Abstract

Without treatment, Cushing’s disease has significant morbidity and mortality. Where a surgical approach may not be feasible, or is refused by the patient, medical therapy becomes the only option. In this case report, we discuss the effects of two years of ketoconazole treatment on diabetes regulation and insulin resistance in a patient reluctant to agree to surgery. A 62 year-old female patient with uncontrolled type 2 diabetes mellitus was investigated. Cushing’s disease was confirmed by the results of high urine free cortisol level and dexamethasone suppression tests.
We discuss the effects of two years of 600 mg/day ketoconazole treatment on diabetes regulation and insulin resistance in a patient with Cushing’s disease reluctant to agree to surgery. This case report illustrates the beneficial long-term effects of 24 months of ketoconazole treatment on the clinical and laboratory findings and also on steroid and glucose metabolism. (Pol J Endocrinol 2011; 62 (3): 271–274)

Abstract

Without treatment, Cushing’s disease has significant morbidity and mortality. Where a surgical approach may not be feasible, or is refused by the patient, medical therapy becomes the only option. In this case report, we discuss the effects of two years of ketoconazole treatment on diabetes regulation and insulin resistance in a patient reluctant to agree to surgery. A 62 year-old female patient with uncontrolled type 2 diabetes mellitus was investigated. Cushing’s disease was confirmed by the results of high urine free cortisol level and dexamethasone suppression tests.
We discuss the effects of two years of 600 mg/day ketoconazole treatment on diabetes regulation and insulin resistance in a patient with Cushing’s disease reluctant to agree to surgery. This case report illustrates the beneficial long-term effects of 24 months of ketoconazole treatment on the clinical and laboratory findings and also on steroid and glucose metabolism. (Pol J Endocrinol 2011; 62 (3): 271–274)
Get Citation

Keywords

Cushing’s disease; ketoconazole; insulin resistance; HOMA

About this article
Title

Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing’s disease resistant to surgery

Journal

Endokrynologia Polska

Issue

Vol 62, No 3 (2011)

Pages

271-274

Published online

2011-06-29

Bibliographic record

Endokrynologia Polska 2011;62(3):271-274.

Keywords

Cushing’s disease
ketoconazole
insulin resistance
HOMA

Authors

Meral Mert
Gonenc Kocabay

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