open access

Vol 62, No 3 (2011)
Original papers
Published online: 2011-06-29
Submitted: 2013-02-15
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Interactive effects of melatonin, exercise and diabetes on liver glycogen levels

Mursel Bicer, Mustafa Akil, Mustafa Cihat Avunduk, Mehmet Kilic, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Endokrynologia Polska 2011;62(3):252-256.

open access

Vol 62, No 3 (2011)
Original papers
Published online: 2011-06-29
Submitted: 2013-02-15

Abstract

Background: This study aimed to examine the effects of melatonin supplementation on liver glycogen levels in rats with streptozotocin- induced diabetes and subjected to acute swimming exercise.
Material and methods: Eighty Sprague-Dawley type adult male rats were divided into eight groups: Group 1, general control; Group 2, melatonin-supplemented control; Group 3, melatonin-supplemented diabetes; Group 4, swimming control; Group 5, melatonin-supplemented swimming; Group 6, melatonin-supplemented diabetic swimming; Group 7, diabetic swimming; Group 8, diabetic control. Melatonin was supplemented at a dose of 3 mg/kg/day intraperitoneally for four weeks. Liver tissue samples were collected and evaluated using a Nikon Eclipse E400 light microscope. All images obtained from the light microscope were transferred to PC medium and evaluated using Clemex PE 3.5 image analysis software.
Results: The lowest liver glycogen levels in the study were found in group 4. Liver glycogen levels in groups 3, 6, 7 and 8 (the diabetic groups) were higher than group 4, but lower than those in groups 1 and 2. The lowest liver glycogen levels were obtained in groups 1 and 2.
Conclusions: The study indicates that melatonin supplementation maintains the liver glycogen levels that decrease in acute swimming exercise, while induced diabetes prevents this maintenance effect in rats. (Pol J Endocrinol 2011; 62 (3): 252–255)

Abstract

Background: This study aimed to examine the effects of melatonin supplementation on liver glycogen levels in rats with streptozotocin- induced diabetes and subjected to acute swimming exercise.
Material and methods: Eighty Sprague-Dawley type adult male rats were divided into eight groups: Group 1, general control; Group 2, melatonin-supplemented control; Group 3, melatonin-supplemented diabetes; Group 4, swimming control; Group 5, melatonin-supplemented swimming; Group 6, melatonin-supplemented diabetic swimming; Group 7, diabetic swimming; Group 8, diabetic control. Melatonin was supplemented at a dose of 3 mg/kg/day intraperitoneally for four weeks. Liver tissue samples were collected and evaluated using a Nikon Eclipse E400 light microscope. All images obtained from the light microscope were transferred to PC medium and evaluated using Clemex PE 3.5 image analysis software.
Results: The lowest liver glycogen levels in the study were found in group 4. Liver glycogen levels in groups 3, 6, 7 and 8 (the diabetic groups) were higher than group 4, but lower than those in groups 1 and 2. The lowest liver glycogen levels were obtained in groups 1 and 2.
Conclusions: The study indicates that melatonin supplementation maintains the liver glycogen levels that decrease in acute swimming exercise, while induced diabetes prevents this maintenance effect in rats. (Pol J Endocrinol 2011; 62 (3): 252–255)
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Keywords

melatonin; diabetes; acute swimming exercise; glycogen

About this article
Title

Interactive effects of melatonin, exercise and diabetes on liver glycogen levels

Journal

Endokrynologia Polska

Issue

Vol 62, No 3 (2011)

Pages

252-256

Published online

2011-06-29

Bibliographic record

Endokrynologia Polska 2011;62(3):252-256.

Keywords

melatonin
diabetes
acute swimming exercise
glycogen

Authors

Mursel Bicer
Mustafa Akil
Mustafa Cihat Avunduk
Mehmet Kilic
Rasim Mogulkoc
Abdulkerim Kasim Baltaci

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