open access

Vol 62, No 3 (2011)
Original papers
Published online: 2011-06-29
Submitted: 2013-02-15
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Selected markers of endothelial dysfunction in women with polycystic ovary syndrome

Wanda Foltyn, Janusz Strzelczyk, Bogan Marek, Dariusz Kajdaniuk, Lucyna Siemińska, Anna Zemczak, Jolanta Blicharz-Dorniak, Beata Kos-Kudła
Endokrynologia Polska 2011;62(3):243-248.

open access

Vol 62, No 3 (2011)
Original papers
Published online: 2011-06-29
Submitted: 2013-02-15

Abstract

Background: The increased incidence of cardiovascular disease in women with polycystic ovary syndrome (PCOS) has prompted researchers to look for indicators of early atherosclerotic changes in these patients. One of the earliest stages of atherogenesis is endothelial cell dysfunction. The aim of this study was to assess the levels of selected plasma markers of endothelial injury [E-selectin, endothelin-1 (ET-1) and von Willebrand Factor antigen (vWF:Ag)] in PCOS women before and after six months of treatment.
Material and methods: 32 patients with PCOS aged 18–36 years (mean age 25.16 ± 5.80) were included in the study. The control group consisted of 20 healthy women matched for age and body mass. The levels of ET-1, vWF:Ag, E-selectin, fasting glucose, insulin, total cholesterol, HDL and LDL-cholesterol and triglycerides were assessed. In the PCOS group, all these tests were repeated after six months of treatment.
Results: The study showed higher levels of vWF:Ag (p = 0.043), E selectin (p = 0.028), insulin (p = 0.044), glucose (p = 0.036) and LDL (p = 0.006) in PCOS patients versus healthy women. A positive correlation was demonstrated between E selectin and glucose (p = 0.0001), triglycerides (p = 0.014) and uric acid (p = 0.008). vWF:Ag levels showed a positive correlation with glucose (p = 0.04) and triglycerides (p = 0.036). A positive correlation was also found between ET-1 and total cholesterol levels (p = 0.012) in PCOS women. After treatment, there was a significant reduction in E-selectin levels from baseline (p = 0.002) and an increase in the levels of HDL (p = 0.0002) and triglycerides (p = 0.033).
Conclusions: Elevated levels of vWF:Ag and E selectin in PCOS women suggest endothelial dysfunction in this group of patients. Glucose and triglyceride are significant factors affecting endothelial function in PCOS. (Pol J Endocrinol 2011; 62 (3): 243–248)

Abstract

Background: The increased incidence of cardiovascular disease in women with polycystic ovary syndrome (PCOS) has prompted researchers to look for indicators of early atherosclerotic changes in these patients. One of the earliest stages of atherogenesis is endothelial cell dysfunction. The aim of this study was to assess the levels of selected plasma markers of endothelial injury [E-selectin, endothelin-1 (ET-1) and von Willebrand Factor antigen (vWF:Ag)] in PCOS women before and after six months of treatment.
Material and methods: 32 patients with PCOS aged 18–36 years (mean age 25.16 ± 5.80) were included in the study. The control group consisted of 20 healthy women matched for age and body mass. The levels of ET-1, vWF:Ag, E-selectin, fasting glucose, insulin, total cholesterol, HDL and LDL-cholesterol and triglycerides were assessed. In the PCOS group, all these tests were repeated after six months of treatment.
Results: The study showed higher levels of vWF:Ag (p = 0.043), E selectin (p = 0.028), insulin (p = 0.044), glucose (p = 0.036) and LDL (p = 0.006) in PCOS patients versus healthy women. A positive correlation was demonstrated between E selectin and glucose (p = 0.0001), triglycerides (p = 0.014) and uric acid (p = 0.008). vWF:Ag levels showed a positive correlation with glucose (p = 0.04) and triglycerides (p = 0.036). A positive correlation was also found between ET-1 and total cholesterol levels (p = 0.012) in PCOS women. After treatment, there was a significant reduction in E-selectin levels from baseline (p = 0.002) and an increase in the levels of HDL (p = 0.0002) and triglycerides (p = 0.033).
Conclusions: Elevated levels of vWF:Ag and E selectin in PCOS women suggest endothelial dysfunction in this group of patients. Glucose and triglyceride are significant factors affecting endothelial function in PCOS. (Pol J Endocrinol 2011; 62 (3): 243–248)
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Keywords

polycystic ovary syndrome; endothelium; E-selectin; von Willebrand factor; endothelin-1

About this article
Title

Selected markers of endothelial dysfunction in women with polycystic ovary syndrome

Journal

Endokrynologia Polska

Issue

Vol 62, No 3 (2011)

Pages

243-248

Published online

2011-06-29

Bibliographic record

Endokrynologia Polska 2011;62(3):243-248.

Keywords

polycystic ovary syndrome
endothelium
E-selectin
von Willebrand factor
endothelin-1

Authors

Wanda Foltyn
Janusz Strzelczyk
Bogan Marek
Dariusz Kajdaniuk
Lucyna Siemińska
Anna Zemczak
Jolanta Blicharz-Dorniak
Beata Kos-Kudła

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