open access

Vol 62, No 5 (2011)
Original papers
Published online: 2011-11-08
Submitted: 2013-02-15
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Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women

Banu Kale Koroglu, Fatma Kiris, Ismail Hakki Ersoy, Recep Sutcu, Mustafa Yildiz, Oguzhan Aksu, Fatih Ermis, Sidika Ersoy, Mehmet Numan Tamer
Endokrynologia Polska 2011;62(5):429-435.

open access

Vol 62, No 5 (2011)
Original papers
Published online: 2011-11-08
Submitted: 2013-02-15

Abstract

Background: Our aim is to identify the relation of leptin, adiponectin and insulin resistance to bone mineral density (BMD) in type 2 diabetic postmenopausal women and compare it with that experienced by nondiabetics.
Material and methods: Seventy six postmenopausal female patients were included in the study. Postmenopausal type 2 diabetic (n = 19) and nondiabetic patients (n = 19) with spine and/or hip BMD T score lower than -2 were included in the study, and postmenopausal type 2 diabetic (n = 20) and nondiabetic women (n = 18) with normal BMD (T score > –1) were selected as control groups. Those receiving therapy for osteoporosis, over the age of 65, those who had a disease and were taking a medication that could affect bone metabolism were excluded. Biochemical tests, as well as leptin, adiponectin and insulin levels, were measured and insulin resistance was calculated using the HOMA test.
Results: There was no correlation between low BMD and leptin, adiponectin and insulin resistance. There was only a negative correlation between leptin and femur Ward’s triangle BMD.
Conclusion: Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients. (Pol J Endocrinol 2011; 62 (5): 429–435)

Abstract

Background: Our aim is to identify the relation of leptin, adiponectin and insulin resistance to bone mineral density (BMD) in type 2 diabetic postmenopausal women and compare it with that experienced by nondiabetics.
Material and methods: Seventy six postmenopausal female patients were included in the study. Postmenopausal type 2 diabetic (n = 19) and nondiabetic patients (n = 19) with spine and/or hip BMD T score lower than -2 were included in the study, and postmenopausal type 2 diabetic (n = 20) and nondiabetic women (n = 18) with normal BMD (T score > –1) were selected as control groups. Those receiving therapy for osteoporosis, over the age of 65, those who had a disease and were taking a medication that could affect bone metabolism were excluded. Biochemical tests, as well as leptin, adiponectin and insulin levels, were measured and insulin resistance was calculated using the HOMA test.
Results: There was no correlation between low BMD and leptin, adiponectin and insulin resistance. There was only a negative correlation between leptin and femur Ward’s triangle BMD.
Conclusion: Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients. (Pol J Endocrinol 2011; 62 (5): 429–435)
Get Citation

Keywords

leptin; adinopectin; insulin resistance; bone mineral density

About this article
Title

Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women

Journal

Endokrynologia Polska

Issue

Vol 62, No 5 (2011)

Pages

429-435

Published online

2011-11-08

Bibliographic record

Endokrynologia Polska 2011;62(5):429-435.

Keywords

leptin
adinopectin
insulin resistance
bone mineral density

Authors

Banu Kale Koroglu
Fatma Kiris
Ismail Hakki Ersoy
Recep Sutcu
Mustafa Yildiz
Oguzhan Aksu
Fatih Ermis
Sidika Ersoy
Mehmet Numan Tamer

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