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Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women
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Abstract
Material and methods: Seventy six postmenopausal female patients were included in the study. Postmenopausal type 2 diabetic (n = 19) and nondiabetic patients (n = 19) with spine and/or hip BMD T score lower than -2 were included in the study, and postmenopausal type 2 diabetic (n = 20) and nondiabetic women (n = 18) with normal BMD (T score > –1) were selected as control groups. Those receiving therapy for osteoporosis, over the age of 65, those who had a disease and were taking a medication that could affect bone metabolism were excluded. Biochemical tests, as well as leptin, adiponectin and insulin levels, were measured and insulin resistance was calculated using the HOMA test.
Results: There was no correlation between low BMD and leptin, adiponectin and insulin resistance. There was only a negative correlation between leptin and femur Ward’s triangle BMD.
Conclusion: Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients. (Pol J Endocrinol 2011; 62 (5): 429–435)
Abstract
Material and methods: Seventy six postmenopausal female patients were included in the study. Postmenopausal type 2 diabetic (n = 19) and nondiabetic patients (n = 19) with spine and/or hip BMD T score lower than -2 were included in the study, and postmenopausal type 2 diabetic (n = 20) and nondiabetic women (n = 18) with normal BMD (T score > –1) were selected as control groups. Those receiving therapy for osteoporosis, over the age of 65, those who had a disease and were taking a medication that could affect bone metabolism were excluded. Biochemical tests, as well as leptin, adiponectin and insulin levels, were measured and insulin resistance was calculated using the HOMA test.
Results: There was no correlation between low BMD and leptin, adiponectin and insulin resistance. There was only a negative correlation between leptin and femur Ward’s triangle BMD.
Conclusion: Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients. (Pol J Endocrinol 2011; 62 (5): 429–435)
Keywords
leptin; adinopectin; insulin resistance; bone mineral density
About this articleTitle
Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women
Journal
Issue
Article type
Original paper
Pages
429-435
Published online
2011-11-08
Page views
1101
Article views/downloads
1559
Bibliographic record
Endokrynol Pol 2011;62(5):429-435.
Keywords
leptin
adinopectin
insulin resistance
bone mineral density
Authors
Banu Kale Koroglu
Fatma Kiris
Ismail Hakki Ersoy
Recep Sutcu
Mustafa Yildiz
Oguzhan Aksu
Fatih Ermis
Sidika Ersoy
Mehmet Numan Tamer
