Changes in inflammatory biomarkers after successful lifestyle intervention in obese children

Barbara Garanty-Bogacka; Małgorzata Syrenicz; Joanna Goral; Beata Krupa; Justyna Syrenicz; Mieczysław Walczak; Anhelli Syrenicz

Vol 62, No 6 (2011)

Original paper

Submitted: 2013-02-15

Published online: 2011-12-06

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Changes in inflammatory biomarkers after successful lifestyle intervention in obese children

Barbara Garanty-Bogacka, Małgorzata Syrenicz, Joanna Goral, Beata Krupa, Justyna Syrenicz, Mieczysław Walczak, Anhelli Syrenicz

Endokrynol Pol 2011;62(6):499-505.

Vol 62, No 6 (2011)

Original Paper

Submitted: 2013-02-15

Published online: 2011-12-06

Abstract

Background: Obesity has been associated with low-grade systemic inflammation, potentially leading to insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Even moderate weight loss through dietary changes and physical exercise is effective in preventing and managing obesity-associated disorders. The aim of this study was to determine the effect of weight loss in response to a lifestyle modification on the serum levels of inflammatory markers in obese children and adolescents.
Material and methods: Fifty obese subjects completed a six-month programme consisting of combined hypocaloric diet and moderate physical activity. High-sensitive C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen (FB), white blood count (WBC), glucose, insulin, insulin resistance index (HOMA IR), glycosylated haemoglobin (HbA_1c), lipids as well as systolic (SBP) and diastolic blood pressure (DBP) were measured before and after intervention.
Results: Patients had a 5.3 ± 3.4 kg average weight loss, with significant decreases of SDS-BMI, percentage of body fat, SDS-waist, SBP and DBP, HOMA-IR, HbA_1c and reductions in serum IL-6, CRP, WBC, FB. In the multivariable linear models, changes in percentage of body fat and HOMA-IR were positively associated with favourable changes in inflammatory parameters.
Conclusion: This study demonstrates that weight reduction after successful lifestyle intervention results in improvements of blood inflammatory markers in obese children and adolescents. (Pol J Endocrinol 2011; 62 (6): 499–505)