open access

Vol 62, No 6 (2011)
Original papers
Published online: 2011-12-06
Submitted: 2013-02-15
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Changes in inflammatory biomarkers after successful lifestyle intervention in obese children

Barbara Garanty-Bogacka, Małgorzata Syrenicz, Joanna Goral, Beata Krupa, Justyna Syrenicz, Mieczysław Walczak, Anhelli Syrenicz
Endokrynologia Polska 2011;62(6):499-505.

open access

Vol 62, No 6 (2011)
Original papers
Published online: 2011-12-06
Submitted: 2013-02-15

Abstract

Background: Obesity has been associated with low-grade systemic inflammation, potentially leading to insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Even moderate weight loss through dietary changes and physical exercise is effective in preventing and managing obesity-associated disorders. The aim of this study was to determine the effect of weight loss in response to a lifestyle modification on the serum levels of inflammatory markers in obese children and adolescents.
Material and methods: Fifty obese subjects completed a six-month programme consisting of combined hypocaloric diet and moderate physical activity. High-sensitive C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen (FB), white blood count (WBC), glucose, insulin, insulin resistance index (HOMA IR), glycosylated haemoglobin (HbA1c), lipids as well as systolic (SBP) and diastolic blood pressure (DBP) were measured before and after intervention.
Results: Patients had a 5.3 ± 3.4 kg average weight loss, with significant decreases of SDS-BMI, percentage of body fat, SDS-waist, SBP and DBP, HOMA-IR, HbA1c and reductions in serum IL-6, CRP, WBC, FB. In the multivariable linear models, changes in percentage of body fat and HOMA-IR were positively associated with favourable changes in inflammatory parameters.
Conclusion: This study demonstrates that weight reduction after successful lifestyle intervention results in improvements of blood inflammatory markers in obese children and adolescents. (Pol J Endocrinol 2011; 62 (6): 499–505)

Abstract

Background: Obesity has been associated with low-grade systemic inflammation, potentially leading to insulin resistance, type 2 diabetes, dyslipidemia, and cardiovascular diseases. Even moderate weight loss through dietary changes and physical exercise is effective in preventing and managing obesity-associated disorders. The aim of this study was to determine the effect of weight loss in response to a lifestyle modification on the serum levels of inflammatory markers in obese children and adolescents.
Material and methods: Fifty obese subjects completed a six-month programme consisting of combined hypocaloric diet and moderate physical activity. High-sensitive C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen (FB), white blood count (WBC), glucose, insulin, insulin resistance index (HOMA IR), glycosylated haemoglobin (HbA1c), lipids as well as systolic (SBP) and diastolic blood pressure (DBP) were measured before and after intervention.
Results: Patients had a 5.3 ± 3.4 kg average weight loss, with significant decreases of SDS-BMI, percentage of body fat, SDS-waist, SBP and DBP, HOMA-IR, HbA1c and reductions in serum IL-6, CRP, WBC, FB. In the multivariable linear models, changes in percentage of body fat and HOMA-IR were positively associated with favourable changes in inflammatory parameters.
Conclusion: This study demonstrates that weight reduction after successful lifestyle intervention results in improvements of blood inflammatory markers in obese children and adolescents. (Pol J Endocrinol 2011; 62 (6): 499–505)
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Keywords

inflammatory markers; weight loss; obesity; children

About this article
Title

Changes in inflammatory biomarkers after successful lifestyle intervention in obese children

Journal

Endokrynologia Polska

Issue

Vol 62, No 6 (2011)

Pages

499-505

Published online

2011-12-06

Bibliographic record

Endokrynologia Polska 2011;62(6):499-505.

Keywords

inflammatory markers
weight loss
obesity
children

Authors

Barbara Garanty-Bogacka
Małgorzata Syrenicz
Joanna Goral
Beata Krupa
Justyna Syrenicz
Mieczysław Walczak
Anhelli Syrenicz

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