Vol 62, Supp. I (2011)
Review paper
Submitted: 2013-02-15
Published online: 2011-09-19
Chromogranin A (CgA) — the influence of various factors in vivo and in vitro, and existing disorders on it’s concentration in blood
Piotr Glinicki, Wojciech Jeske
Vol 62, Supp. I (2011)
Review Article
Submitted: 2013-02-15
Published online: 2011-09-19
Abstract
Chromogranin A (CgA) is regarded as a major, nonspecific neuroendocrine tumour (NET) marker. The results of CgA blood concentration,
however, may actually be influenced by various factors or coexisting pathological conditions. Among the factors causing a substantial
increase of the blood CgA concentration are: treatment with proton-pump inhibitors or H2 -receptor blockers, chronic atrophic gastritis
(type A), impaired renal function, prostate cancer and BPH, and rheumatoid arthritis with high level of RF IgM. In addition, the sort of
investigated biological material (whether it is serum or plasma) is of importance.
There are also many conditions which may have a moderate or little influence on the concentration of CgA, among them are: inflammatory
bowel disease (ulcerative colitis and Crohn’s disease), deteriorating liver function, untreated essential hypertension, heart failure, hypercortisolism,
pregnancy, and, in some subjects, ingestion of a meal.
Proper assessment of the CgA results requires detailed knowledge about various factors, drugs, and pathological conditions influencing its
concentration in blood.
(Pol J Endocrinol 2011; 62 (education supplement I): 25–28)
Abstract
Chromogranin A (CgA) is regarded as a major, nonspecific neuroendocrine tumour (NET) marker. The results of CgA blood concentration,
however, may actually be influenced by various factors or coexisting pathological conditions. Among the factors causing a substantial
increase of the blood CgA concentration are: treatment with proton-pump inhibitors or H2 -receptor blockers, chronic atrophic gastritis
(type A), impaired renal function, prostate cancer and BPH, and rheumatoid arthritis with high level of RF IgM. In addition, the sort of
investigated biological material (whether it is serum or plasma) is of importance.
There are also many conditions which may have a moderate or little influence on the concentration of CgA, among them are: inflammatory
bowel disease (ulcerative colitis and Crohn’s disease), deteriorating liver function, untreated essential hypertension, heart failure, hypercortisolism,
pregnancy, and, in some subjects, ingestion of a meal.
Proper assessment of the CgA results requires detailed knowledge about various factors, drugs, and pathological conditions influencing its
concentration in blood.
(Pol J Endocrinol 2011; 62 (education supplement I): 25–28)
Keywords
chromogranin A; neuroendocrine tumours
Title
Chromogranin A (CgA) — the influence of various factors in vivo and in vitro, and existing disorders on it’s concentration in blood
Journal
Endokrynologia Polska
Issue
Vol 62, Supp. I (2011)
Article type
Review paper
Pages
25-28
Published online
2011-09-19
Page views
783
Article views/downloads
2714
Keywords
chromogranin A
neuroendocrine tumours
Authors
Piotr Glinicki
Wojciech Jeske
About this article
