Vol 62, Supp. II (2011)
Review paper
Published online: 2011-09-21
The role of hormonal therapy in osteoporosis
Abstract
In developed societies, the post-menopausal period covers approximately one third of a woman’s life. The deficit of oestrogens observed
during the post-menopausal period significantly affects the course of many metabolic processes, causing a number of diseases and in consequence
diminishing quality of life. Among others, bones belong to oestrogen-dependent tissues. The deficit of the protective influence
of oestrogens compromises the dynamic balance of the bone transformation process towards resorption, thus reducing bone mass and
quality, while increasing the risk of low-energy fractures. In recent years, differing views on the application of oestrogen/gestagen therapy
have reached the level of controversy. The results of numerous clinical studies are far from unequivocal, with the whole subject one of
heated debate. It has been confirmed that hormonal therapy prevents bone quality deterioration, while opening a protective umbrella
around the bone, reducing the risk of osteoporotic fractures. A rational approach to weighing possible advantages against possible risks
and a thorough evaluation of a patient’s health condition allows for optimal therapy selection.
(Pol J Endocrinol 2011; 62 (education supplement II): 19–22)
(Pol J Endocrinol 2011; 62 (education supplement II): 19–22)
Keywords: osteoporosishormone replacement therapybenefitsrisk factors
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