Vol 62, Supp. III (2011)
Review paper
Submitted: 2013-02-15
Published online: 2011-12-08
The role of anorexia nervosa in secondary osteoporosis development with the risk for low energy fractures
Wanda Horst-Sikorska, Magdalena Ignaszak-Szczepaniak
Vol 62, Supp. III (2011)
Review Article
Submitted: 2013-02-15
Published online: 2011-12-08
Abstract
Anorexia nervosa (AN) has in recent years become considerably more common. The disease primarily affects girls and young women, also
boys and young men. AN is a risk factor for secondary osteoporosis. AN-related metabolic disturbances lead to diminished bone quality
and increased risk of fractures. The consequences of low energy fractures are the main causes of death in women with AN. Hormonal
disturbances (e.g. hypoestrogenism, increased levels of ghrelin and Y peptide, changes in leptin and endocannabinoid levels), as well as
the mechanisms involved in bone resorption (RANK/RANKL/OPG system), are considered to be of great importance for anorectic bone
quality. The risk for osteoporotic, non-vertebral fractures in AN patients is significantly higher than in healthy women. Improvement of
bone mineral density is possible after substantial body mass increase. Weight loss, in conjunction with a well-balanced, controlled diet,
is the key to correct peak bone mass levels, and diminishes the risk for osteoporosis with its consequence of low energy bone fractures.
(Pol J Endocrinol 2011; 62 (education supplement III): 1–3<*/i>)
Abstract
Anorexia nervosa (AN) has in recent years become considerably more common. The disease primarily affects girls and young women, also
boys and young men. AN is a risk factor for secondary osteoporosis. AN-related metabolic disturbances lead to diminished bone quality
and increased risk of fractures. The consequences of low energy fractures are the main causes of death in women with AN. Hormonal
disturbances (e.g. hypoestrogenism, increased levels of ghrelin and Y peptide, changes in leptin and endocannabinoid levels), as well as
the mechanisms involved in bone resorption (RANK/RANKL/OPG system), are considered to be of great importance for anorectic bone
quality. The risk for osteoporotic, non-vertebral fractures in AN patients is significantly higher than in healthy women. Improvement of
bone mineral density is possible after substantial body mass increase. Weight loss, in conjunction with a well-balanced, controlled diet,
is the key to correct peak bone mass levels, and diminishes the risk for osteoporosis with its consequence of low energy bone fractures.
(Pol J Endocrinol 2011; 62 (education supplement III): 1–3<*/i>)
Keywords
anorexia nervosa; secondary osteoporosis; risk of fracture
Title
The role of anorexia nervosa in secondary osteoporosis development with the risk for low energy fractures
Journal
Endokrynologia Polska
Issue
Vol 62, Supp. III (2011)
Article type
Review paper
Pages
1-3
Published online
2011-12-08
Page views
479
Article views/downloads
2884
Keywords
anorexia nervosa
secondary osteoporosis
risk of fracture
Authors
Wanda Horst-Sikorska
Magdalena Ignaszak-Szczepaniak
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