open access

Vol 62, Supp. III (2011)
Review article
Published online: 2011-12-08
Submitted: 2013-02-15
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The role of anorexia nervosa in secondary osteoporosis development with the risk for low energy fractures

Wanda Horst-Sikorska, Magdalena Ignaszak-Szczepaniak

open access

Vol 62, Supp. III (2011)
Review article
Published online: 2011-12-08
Submitted: 2013-02-15

Abstract

Anorexia nervosa (AN) has in recent years become considerably more common. The disease primarily affects girls and young women, also boys and young men. AN is a risk factor for secondary osteoporosis. AN-related metabolic disturbances lead to diminished bone quality and increased risk of fractures. The consequences of low energy fractures are the main causes of death in women with AN. Hormonal disturbances (e.g. hypoestrogenism, increased levels of ghrelin and Y peptide, changes in leptin and endocannabinoid levels), as well as the mechanisms involved in bone resorption (RANK/RANKL/OPG system), are considered to be of great importance for anorectic bone quality. The risk for osteoporotic, non-vertebral fractures in AN patients is significantly higher than in healthy women. Improvement of bone mineral density is possible after substantial body mass increase. Weight loss, in conjunction with a well-balanced, controlled diet, is the key to correct peak bone mass levels, and diminishes the risk for osteoporosis with its consequence of low energy bone fractures. (Pol J Endocrinol 2011; 62 (education supplement III): 1–3)

Abstract

Anorexia nervosa (AN) has in recent years become considerably more common. The disease primarily affects girls and young women, also boys and young men. AN is a risk factor for secondary osteoporosis. AN-related metabolic disturbances lead to diminished bone quality and increased risk of fractures. The consequences of low energy fractures are the main causes of death in women with AN. Hormonal disturbances (e.g. hypoestrogenism, increased levels of ghrelin and Y peptide, changes in leptin and endocannabinoid levels), as well as the mechanisms involved in bone resorption (RANK/RANKL/OPG system), are considered to be of great importance for anorectic bone quality. The risk for osteoporotic, non-vertebral fractures in AN patients is significantly higher than in healthy women. Improvement of bone mineral density is possible after substantial body mass increase. Weight loss, in conjunction with a well-balanced, controlled diet, is the key to correct peak bone mass levels, and diminishes the risk for osteoporosis with its consequence of low energy bone fractures. (Pol J Endocrinol 2011; 62 (education supplement III): 1–3)
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Keywords

anorexia nervosa; secondary osteoporosis; risk of fracture

About this article
Title

The role of anorexia nervosa in secondary osteoporosis development with the risk for low energy fractures

Journal

Endokrynologia Polska

Issue

Vol 62, Supp. III (2011)

Pages

1-3

Published online

2011-12-08

Keywords

anorexia nervosa
secondary osteoporosis
risk of fracture

Authors

Wanda Horst-Sikorska
Magdalena Ignaszak-Szczepaniak

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