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Vol 63, No 1 (2012)
Case report
Submitted: 2013-02-15
Published online: 2012-02-29
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Agranulocytosis during treatment of chronic hepatitis C complicated by hyperthyreosis. Case reports

Dorota Kozielewicz, Kornelia Karwowska, Dorota Dybowska, Waldemar Halota
Endokrynol Pol 2012;63(1):52-55.

open access

Vol 63, No 1 (2012)
Case report
Submitted: 2013-02-15
Published online: 2012-02-29

Abstract

Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthyroidism can cause agranulocytosis. The synergistic reaction of ATD and interferon on bone marrow cannot be excluded.

Abstract

Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthyroidism can cause agranulocytosis. The synergistic reaction of ATD and interferon on bone marrow cannot be excluded.

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Keywords

hyperthyroidism; agranulocytosis; anti-thyroid drugs; pegylated interferon alpha; granulocyte colony-stimulating factor

About this article
Title

Agranulocytosis during treatment of chronic hepatitis C complicated by hyperthyreosis. Case reports

Journal

Endokrynologia Polska

Issue

Vol 63, No 1 (2012)

Article type

Case report

Pages

52-55

Published online

2012-02-29

Page views

615

Article views/downloads

1586

Bibliographic record

Endokrynol Pol 2012;63(1):52-55.

Keywords

hyperthyroidism
agranulocytosis
anti-thyroid drugs
pegylated interferon alpha
granulocyte colony-stimulating factor

Authors

Dorota Kozielewicz
Kornelia Karwowska
Dorota Dybowska
Waldemar Halota

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