open access

Vol 63, No 1 (2012)
Case report
Published online: 2012-02-29
Submitted: 2013-02-15
Get Citation

Agranulocytosis during treatment of chronic hepatitis C complicated by hyperthyreosis. Case reports

Dorota Kozielewicz, Kornelia Karwowska, Dorota Dybowska, Waldemar Halota
Endokrynologia Polska 2012;63(1):52-55.

open access

Vol 63, No 1 (2012)
Case report
Published online: 2012-02-29
Submitted: 2013-02-15

Abstract

Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthyroidism can cause agranulocytosis. The synergistic reaction of ATD and interferon on bone marrow cannot be excluded.

Abstract

Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthyroidism can cause agranulocytosis. The synergistic reaction of ATD and interferon on bone marrow cannot be excluded.
Get Citation

Keywords

hyperthyroidism; agranulocytosis; anti-thyroid drugs; pegylated interferon alpha; granulocyte colony-stimulating factor

About this article
Title

Agranulocytosis during treatment of chronic hepatitis C complicated by hyperthyreosis. Case reports

Journal

Endokrynologia Polska

Issue

Vol 63, No 1 (2012)

Pages

52-55

Published online

2012-02-29

Bibliographic record

Endokrynologia Polska 2012;63(1):52-55.

Keywords

hyperthyroidism
agranulocytosis
anti-thyroid drugs
pegylated interferon alpha
granulocyte colony-stimulating factor

Authors

Dorota Kozielewicz
Kornelia Karwowska
Dorota Dybowska
Waldemar Halota

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl