open access

Vol 63, No 2 (2012)
Review article
Published online: 2012-04-27
Submitted: 2013-02-15
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MSI and LOH in the development and prognosis of follicular cell-derived thyroid tumours

Monika Migdalska-Sęk, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska
Endokrynologia Polska 2012;63(2):126-136.

open access

Vol 63, No 2 (2012)
Review article
Published online: 2012-04-27
Submitted: 2013-02-15

Abstract

Microsatellite instability (MSI) and loss of heterozygosity (LOH) represent molecular disorders acquired by the cell during neoplastic transformation. Both are associated with genetic instability. Functional silencing of tumour suppressor genes may be the consequence of genomic instability, particularly of the globally occurring LOH phenomenon. Numerous studies have confirmed the role of MSI/LOH at both the early and the late stages of thyroid tumourigenesis. This paper reviews the available study results on MSI/LOH significance and prevalence in thyroid neoplasms. Additionally, it summarises the knowledge regarding the practical usage of the study findings on MSI/LOH in aspects of cancer risk assessment as well as the development of prognostic markers for thyroid neoplasms. (Pol J Endocrinol 2012; 63 (2): 126–136)

Abstract

Microsatellite instability (MSI) and loss of heterozygosity (LOH) represent molecular disorders acquired by the cell during neoplastic transformation. Both are associated with genetic instability. Functional silencing of tumour suppressor genes may be the consequence of genomic instability, particularly of the globally occurring LOH phenomenon. Numerous studies have confirmed the role of MSI/LOH at both the early and the late stages of thyroid tumourigenesis. This paper reviews the available study results on MSI/LOH significance and prevalence in thyroid neoplasms. Additionally, it summarises the knowledge regarding the practical usage of the study findings on MSI/LOH in aspects of cancer risk assessment as well as the development of prognostic markers for thyroid neoplasms. (Pol J Endocrinol 2012; 63 (2): 126–136)
Get Citation

Keywords

microsatellite instability; loss of heterozygosity; thyroid neoplasms; prognostic marker

About this article
Title

MSI and LOH in the development and prognosis of follicular cell-derived thyroid tumours

Journal

Endokrynologia Polska

Issue

Vol 63, No 2 (2012)

Pages

126-136

Published online

2012-04-27

Bibliographic record

Endokrynologia Polska 2012;63(2):126-136.

Keywords

microsatellite instability
loss of heterozygosity
thyroid neoplasms
prognostic marker

Authors

Monika Migdalska-Sęk
Dorota Pastuszak-Lewandoska
Ewa Brzeziańska

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