MSI and LOH in the development and prognosis of follicular cell-derived thyroid tumours

Monika Migdalska-Sęk; Dorota Pastuszak-Lewandoska; Ewa Brzeziańska

Vol 63, No 2 (2012)

Review paper

Submitted: 2013-02-15

Published online: 2012-04-27

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MSI and LOH in the development and prognosis of follicular cell-derived thyroid tumours

Monika Migdalska-Sęk, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska

Endokrynol Pol 2012;63(2):126-136.

Vol 63, No 2 (2012)

Review Article

Submitted: 2013-02-15

Published online: 2012-04-27

Abstract

Microsatellite instability (MSI) and loss of heterozygosity (LOH) represent molecular disorders acquired by the cell during neoplastic transformation. Both are associated with genetic instability. Functional silencing of tumour suppressor genes may be the consequence of genomic instability, particularly of the globally occurring LOH phenomenon. Numerous studies have confirmed the role of MSI/LOH at both the early and the late stages of thyroid tumourigenesis. This paper reviews the available study results on MSI/LOH significance and prevalence in thyroid neoplasms. Additionally, it summarises the knowledge regarding the practical usage of the study findings on MSI/LOH in aspects of cancer risk assessment as well as the development of prognostic markers for thyroid neoplasms. (Pol J Endocrinol 2012; 63 (2): 126–136)