open access

Vol 63, No 4 (2012)
Original papers
Published online: 2012-08-30
Submitted: 2013-02-15
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Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia

Aysegul Ugur Kurtoglu, Erdal Kurtoglu, A. Kamil Temizkan
Endokrynologia Polska 2012;63(4):260-263.

open access

Vol 63, No 4 (2012)
Original papers
Published online: 2012-08-30
Submitted: 2013-02-15

Abstract


Introduction:
Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia.
Materials and methods: We ordered following tests for consideration endocrine abnormalities: fasting plasma glucose, oral glucose tolerance, iron, total iron binding capacity, ferritin, thyroid-stimulating hormone (TSH), free thyroxin (fT4), free triiodothyronine (fT3), parathyroid hormone levels.
Results: According to our study including 70 patients with thalassemia major, 7 (10%) had diabetes, 5 (7.1%) had impaired glucose tolerance, 9 (12.8%) had hypothyroidism, 2 (2.8%) had hypoparathyroidism, 2 (2.8%) had hyperparathyroidism. Of 22 patients with thalassemia intermedia, 1 (4.5%) had diabetes.
Conclusions: These findings reinforce the importance of regular follow-up of patients with b-thalassemia major and thalassemia intermedia for early detection and management of associated complications. In this way, the prevalence of endocrine abnormalities can be decreased in future.

Abstract


Introduction:
Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia.
Materials and methods: We ordered following tests for consideration endocrine abnormalities: fasting plasma glucose, oral glucose tolerance, iron, total iron binding capacity, ferritin, thyroid-stimulating hormone (TSH), free thyroxin (fT4), free triiodothyronine (fT3), parathyroid hormone levels.
Results: According to our study including 70 patients with thalassemia major, 7 (10%) had diabetes, 5 (7.1%) had impaired glucose tolerance, 9 (12.8%) had hypothyroidism, 2 (2.8%) had hypoparathyroidism, 2 (2.8%) had hyperparathyroidism. Of 22 patients with thalassemia intermedia, 1 (4.5%) had diabetes.
Conclusions: These findings reinforce the importance of regular follow-up of patients with b-thalassemia major and thalassemia intermedia for early detection and management of associated complications. In this way, the prevalence of endocrine abnormalities can be decreased in future.
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Keywords

iron overload; endocrine abnormalities; thalassemia major; thalassemia intermedia

About this article
Title

Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia

Journal

Endokrynologia Polska

Issue

Vol 63, No 4 (2012)

Pages

260-263

Published online

2012-08-30

Bibliographic record

Endokrynologia Polska 2012;63(4):260-263.

Keywords

iron overload
endocrine abnormalities
thalassemia major
thalassemia intermedia

Authors

Aysegul Ugur Kurtoglu
Erdal Kurtoglu
A. Kamil Temizkan

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