open access

Vol 63, No 5 (2012)
Original papers
Published online: 2012-10-31
Submitted: 2013-02-15
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Glycated haemoglobin is correlated with the severity of coronary artery disease independently of traditional risk factors in young patients

S. Selim Ayhan, Mehmet Tosun, Serkan Ozturk, Aytekin Alcelik, Mehmet Fatih Ozlu, . Alim Erdem, Kemalettin Erdem, Fatma Hizal Erdem, Mehmet Yazici
Endokrynologia Polska 2012;63(5):367-371.

open access

Vol 63, No 5 (2012)
Original papers
Published online: 2012-10-31
Submitted: 2013-02-15

Abstract


Introduction: In this study, we aimed to investigate the relationship between glycated haemoglobin (HbA1c) levels and the severity of coronary artery disease (CAD) in < 40 years old patients.
Material and methods: The study population consisted of 211 premature coronary atherosclerotic patients (pCAP) (aged 36.4 ± 2.5 years) and 160 control subjects (36.4 ± 2.4 years). The severity of CAD was evaluated by the Gensini scoring system. HbA1c levels and the other basic biochemical parameters were analysed, and relations with severity of CAD were evaluated.
Results: There were statistically significant differences in serum HbA1c levels between the two groups (pCAP = 6.1 ± 1.8%, control = 4.7 ± 1.2%, p < 0.001). HbA1c levels significantly positively correlated with the Gensini score in pCAP (r = 0.662, p < 0.001). In linear multivariate regression analysis (including age, sex, HbA1c, smoking, diabetes mellitus and hypertension as dependent parameters), only HbA1c was found to be an independent risk factor for the presence of severe CAD (Beta = 0.374, p < 0.001). In ROC curve analysis, the optimal cut-off value of HbA1c to predict severe CAD was 6.52%, with 74.4% sensitivity and 75.1% specificity (area under the curve 0.781, 95% confidence interval 0.661 to 0.901, p < 0.001).
Conclusions: HbA1c levels were found to be correlated with the Gensini score in pCAP with and without diabetes. In this respect, glucose metabolism abnormalities, indicated by HbA1c, may play an important role in premature CAD. (Endokrynol Pol 2012; 63 (5): 367-371)

Abstract


Introduction: In this study, we aimed to investigate the relationship between glycated haemoglobin (HbA1c) levels and the severity of coronary artery disease (CAD) in < 40 years old patients.
Material and methods: The study population consisted of 211 premature coronary atherosclerotic patients (pCAP) (aged 36.4 ± 2.5 years) and 160 control subjects (36.4 ± 2.4 years). The severity of CAD was evaluated by the Gensini scoring system. HbA1c levels and the other basic biochemical parameters were analysed, and relations with severity of CAD were evaluated.
Results: There were statistically significant differences in serum HbA1c levels between the two groups (pCAP = 6.1 ± 1.8%, control = 4.7 ± 1.2%, p < 0.001). HbA1c levels significantly positively correlated with the Gensini score in pCAP (r = 0.662, p < 0.001). In linear multivariate regression analysis (including age, sex, HbA1c, smoking, diabetes mellitus and hypertension as dependent parameters), only HbA1c was found to be an independent risk factor for the presence of severe CAD (Beta = 0.374, p < 0.001). In ROC curve analysis, the optimal cut-off value of HbA1c to predict severe CAD was 6.52%, with 74.4% sensitivity and 75.1% specificity (area under the curve 0.781, 95% confidence interval 0.661 to 0.901, p < 0.001).
Conclusions: HbA1c levels were found to be correlated with the Gensini score in pCAP with and without diabetes. In this respect, glucose metabolism abnormalities, indicated by HbA1c, may play an important role in premature CAD. (Endokrynol Pol 2012; 63 (5): 367-371)
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Keywords

glycated haemoglobin; premature coronary artery disease; Gensini score

About this article
Title

Glycated haemoglobin is correlated with the severity of coronary artery disease independently of traditional risk factors in young patients

Journal

Endokrynologia Polska

Issue

Vol 63, No 5 (2012)

Pages

367-371

Published online

2012-10-31

Bibliographic record

Endokrynologia Polska 2012;63(5):367-371.

Keywords

glycated haemoglobin
premature coronary artery disease
Gensini score

Authors

S. Selim Ayhan
Mehmet Tosun
Serkan Ozturk
Aytekin Alcelik
Mehmet Fatih Ozlu
. Alim Erdem
Kemalettin Erdem
Fatma Hizal Erdem
Mehmet Yazici

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