open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15
Get Citation

The role of orexin A in metabolic disturbances in patients with acromegaly

Aleksandra Jawiarczyk-Przybyłowska, Marek Bolanowski
Endokrynologia Polska 2012;63(6):463-469.

open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15

Abstract


Introduction: It has been reported that orexins may play an important role in GH regulation. Orexins participate in the regulation of pituitary hormones secretion, food intake regulation, and the sleep-wake cycle. It has been suggested that a defect of orexin A synthesis could be responsible for disturbances in GH synthesis in patients with acromegaly, and consequently aggravate metabolic disturbances caused by high levels of IGF1. The aim of this study: The aim of this study was to assess orexin A levels in relation to the activity of the disease and the influence on metabolic profile in patients with acromegaly.
Material and methods: The subjects were 55 acromegalic patients divided into three main groups: a surgically cured acromegalic group (SCA); a well-controlled acromegalic group (WCA); an active acromegalic group (AA); and 29 healthy controls. In all subjects, blood samples were taken to assess the concentration of orexin A, lipids, glucose, insulin and hormones of the pituitary and peripheral glands.
Results: The concentration of orexin A was highest in the control group (CG) and lowest in the WCA group. The differences of orexin A concentration were statistically significant when each group of acromegalics were compared to the CG. There were no significant differences in orexin A concentration among the studied groups of patients with acromegaly. The metabolic disturbances were more often observed in the groups of acromegaly patients. In the AA group, orexin A concentrations correlated negatively with plasma lipids.
Conclusions: The concentration of orexin A is reduced in acromegaly compared to healthy subjects. (Endokrynol Pol 2012; 63 (6): 463–469)

Abstract


Introduction: It has been reported that orexins may play an important role in GH regulation. Orexins participate in the regulation of pituitary hormones secretion, food intake regulation, and the sleep-wake cycle. It has been suggested that a defect of orexin A synthesis could be responsible for disturbances in GH synthesis in patients with acromegaly, and consequently aggravate metabolic disturbances caused by high levels of IGF1. The aim of this study: The aim of this study was to assess orexin A levels in relation to the activity of the disease and the influence on metabolic profile in patients with acromegaly.
Material and methods: The subjects were 55 acromegalic patients divided into three main groups: a surgically cured acromegalic group (SCA); a well-controlled acromegalic group (WCA); an active acromegalic group (AA); and 29 healthy controls. In all subjects, blood samples were taken to assess the concentration of orexin A, lipids, glucose, insulin and hormones of the pituitary and peripheral glands.
Results: The concentration of orexin A was highest in the control group (CG) and lowest in the WCA group. The differences of orexin A concentration were statistically significant when each group of acromegalics were compared to the CG. There were no significant differences in orexin A concentration among the studied groups of patients with acromegaly. The metabolic disturbances were more often observed in the groups of acromegaly patients. In the AA group, orexin A concentrations correlated negatively with plasma lipids.
Conclusions: The concentration of orexin A is reduced in acromegaly compared to healthy subjects. (Endokrynol Pol 2012; 63 (6): 463–469)
Get Citation

Keywords

acromegaly; orexin A; metabolic disturbances

About this article
Title

The role of orexin A in metabolic disturbances in patients with acromegaly

Journal

Endokrynologia Polska

Issue

Vol 63, No 6 (2012)

Pages

463-469

Published online

2013-01-02

Bibliographic record

Endokrynologia Polska 2012;63(6):463-469.

Keywords

acromegaly
orexin A
metabolic disturbances

Authors

Aleksandra Jawiarczyk-Przybyłowska
Marek Bolanowski

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl