open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15
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Ghrelin and obestatin in thyroid dysfunction

Edyta Gurgul, Marek Ruchała, Jerzy Kosowicz, Hanna Zamysłowska, Elżbieta Wrotkowska, Jerzy Moczko, Jerzy Sowiński
Endokrynologia Polska 2012;63(6):456-462.

open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15

Abstract


Introduction: Ghrelin and obestatin derive from the same precursor. Ghrelin is an energy balance regulator and obestatin’s role in metabolic processes cannot be excluded. The aim of this study was to assess plasma ghrelin and obestatin changes in thyroid disorders.
Material and methods: We evaluated plasma ghrelin and obestatin levels in severe hypothyroidism, hypothyroidism after thyreoidectomy and 4-weeks L-thyroxine withdrawal, and in hyperthyroidism. We also re-evaluated plasma ghrelin and obestatin levels in patients with severe hypothyroidism and hyperthyroidism after treatment.
Results: Severe hypothyroidism was associated with a reasonably high ghrelin level (p = 0.055) and hyperthyroidism with a significantly lower ghrelin level (p = 0.01) compared to healthy subjects. Ghrelin in hypothyroid patients after L-thyroxine withdrawal did not differ from the control group (p = 0.3). Compared to healthy subjects, obestatin level in hyperthyroidism was decreased (p = 0.03) and did not differ in severe hypothyroidism due to thyroiditis (p = 1) or after L-thyroxine withdrawal (p = 0.6). Ghrelin and obestatin levels correlated positively. Both peptides levels correlated positively with TSH and negatively with free thyroid hormones. In patients with severe hypothyroidism, ghrelin level significantly decreased after treatment (p < 0.01) and in hyperthyroid patients significantly increased after treatment (p = 0.04). There were no significant changes in obestatin levels in hypo- or hyperthyroid patients after treatment.
Conclusions: Plasma ghrelin changes and its correlation with TSH and thyroid hormones may indicate a compensatory role of ghrelin in metabolic disturbances associated with thyroid dysfunction. The positive correlation between ghrelin and obestatin levels may suggest a modulatory role of obestatin in these processes. (Endokrynol Pol 2012; 63 (6): 456&#8211;462)

Abstract


Introduction: Ghrelin and obestatin derive from the same precursor. Ghrelin is an energy balance regulator and obestatin&#8217;s role in metabolic processes cannot be excluded. The aim of this study was to assess plasma ghrelin and obestatin changes in thyroid disorders.
Material and methods: We evaluated plasma ghrelin and obestatin levels in severe hypothyroidism, hypothyroidism after thyreoidectomy and 4-weeks L-thyroxine withdrawal, and in hyperthyroidism. We also re-evaluated plasma ghrelin and obestatin levels in patients with severe hypothyroidism and hyperthyroidism after treatment.
Results: Severe hypothyroidism was associated with a reasonably high ghrelin level (p = 0.055) and hyperthyroidism with a significantly lower ghrelin level (p = 0.01) compared to healthy subjects. Ghrelin in hypothyroid patients after L-thyroxine withdrawal did not differ from the control group (p = 0.3). Compared to healthy subjects, obestatin level in hyperthyroidism was decreased (p = 0.03) and did not differ in severe hypothyroidism due to thyroiditis (p = 1) or after L-thyroxine withdrawal (p = 0.6). Ghrelin and obestatin levels correlated positively. Both peptides levels correlated positively with TSH and negatively with free thyroid hormones. In patients with severe hypothyroidism, ghrelin level significantly decreased after treatment (p < 0.01) and in hyperthyroid patients significantly increased after treatment (p = 0.04). There were no significant changes in obestatin levels in hypo- or hyperthyroid patients after treatment.
Conclusions: Plasma ghrelin changes and its correlation with TSH and thyroid hormones may indicate a compensatory role of ghrelin in metabolic disturbances associated with thyroid dysfunction. The positive correlation between ghrelin and obestatin levels may suggest a modulatory role of obestatin in these processes. (Endokrynol Pol 2012; 63 (6): 456&#8211;462)
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Keywords

ghrelin; obestatin; thyroid; hypothyroidism; hyperthyroidism

About this article
Title

Ghrelin and obestatin in thyroid dysfunction

Journal

Endokrynologia Polska

Issue

Vol 63, No 6 (2012)

Pages

456-462

Published online

2013-01-02

Bibliographic record

Endokrynologia Polska 2012;63(6):456-462.

Keywords

ghrelin
obestatin
thyroid
hypothyroidism
hyperthyroidism

Authors

Edyta Gurgul
Marek Ruchała
Jerzy Kosowicz
Hanna Zamysłowska
Elżbieta Wrotkowska
Jerzy Moczko
Jerzy Sowiński

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