open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15
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Total and high molecular weight adiponectin and level-modifying polymorphisms of ADIPOQ in centenarians

Małgorzata Roszkowska-Gancarz, Zbigniew Bartoszewicz, Jacek Polosak, Alina Kurylowicz, Marta Jonas, Małgorzata Mossakowska, Edward Franek, Monika Puzianowska-Kuźnicka
Endokrynologia Polska 2012;63(6):439-446.

open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15

Abstract


Introduction: G promoter polymorphisms of ADIPOQ gene influence the level of circulating adiponectin. We examined the level of total and high molecular weight (HMW) adiponectin in centenarians and associated it with biochemical parameters. We checked if the expression and concentration-modifying polymorphisms of ADIPOQ are associated with extreme longevity.
Material and methods: Total and HMW adiponectin were examined using ELISA in 40 female centenarians. The frequencies of the ADIPOQ polymorphisms were tested by restriction fragment length polymorphism in 148 centenarians, 414 young controls, in 207 myocardial infarction patients, and in 190 type 2 diabetes mellitus patients.
Results: A polymorphism was significantly more common in centenarians than in young controls (p = 0.026) and, while compared to the GG genotype, it was associated with a 2.4-fold higher mean concentration of total adiponectin (26.53 ± 13.29 mg/ mL v. 10.97 ± 4.28 mg/mL) and with an almost 3-fold higher mean HMW adiponectin (20.65 ± 12.72 mg/mL v. 7.36 ± 3.35 mg/mL).
Conclusions: Serum adiponectin concentration in female centenarians is associated with biochemical parameters that are favourable for cardiovascular risk. We suggest that adiponectin might be of importance for extreme longevity. (Endokrynol Pol 2012; 63 (6): 439–446)

Abstract


Introduction: G promoter polymorphisms of ADIPOQ gene influence the level of circulating adiponectin. We examined the level of total and high molecular weight (HMW) adiponectin in centenarians and associated it with biochemical parameters. We checked if the expression and concentration-modifying polymorphisms of ADIPOQ are associated with extreme longevity.
Material and methods: Total and HMW adiponectin were examined using ELISA in 40 female centenarians. The frequencies of the ADIPOQ polymorphisms were tested by restriction fragment length polymorphism in 148 centenarians, 414 young controls, in 207 myocardial infarction patients, and in 190 type 2 diabetes mellitus patients.
Results: A polymorphism was significantly more common in centenarians than in young controls (p = 0.026) and, while compared to the GG genotype, it was associated with a 2.4-fold higher mean concentration of total adiponectin (26.53 ± 13.29 mg/ mL v. 10.97 ± 4.28 mg/mL) and with an almost 3-fold higher mean HMW adiponectin (20.65 ± 12.72 mg/mL v. 7.36 ± 3.35 mg/mL).
Conclusions: Serum adiponectin concentration in female centenarians is associated with biochemical parameters that are favourable for cardiovascular risk. We suggest that adiponectin might be of importance for extreme longevity. (Endokrynol Pol 2012; 63 (6): 439–446)
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Keywords

total and high molecular weight (HMW) adiponectin; adiponectin gene (ADIPOQ); polymorphism; centenarians; myocardial infarction (MI); type 2 diabetes mellitus (DM2)

About this article
Title

Total and high molecular weight adiponectin and level-modifying polymorphisms of ADIPOQ in centenarians

Journal

Endokrynologia Polska

Issue

Vol 63, No 6 (2012)

Pages

439-446

Published online

2013-01-02

Bibliographic record

Endokrynologia Polska 2012;63(6):439-446.

Keywords

total and high molecular weight (HMW) adiponectin
adiponectin gene (ADIPOQ)
polymorphism
centenarians
myocardial infarction (MI)
type 2 diabetes mellitus (DM2)

Authors

Małgorzata Roszkowska-Gancarz
Zbigniew Bartoszewicz
Jacek Polosak
Alina Kurylowicz
Marta Jonas
Małgorzata Mossakowska
Edward Franek
Monika Puzianowska-Kuźnicka

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