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Adiponectin and resistin in relationship with skeletal status in women from the RAC-OST-POL study
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Abstract
Introduction: The aim of this study was to establish adiponectin and resistin serum levels and their relationship with skeletal status in women from the RAC-OST-POL study.
Material and methods: 40 women with the lowest and 40 women with the highest value of bone mineral density (BMD) measured at the femoral neck (FN) were selected from a total of 625 women after dividing them into six age categories. Mean age in the whole group of 80 women was 66.1 ± 8.0 years. 22 women had osteoporotic fractures. Adiponectin and resistin were measured, and skeletal assessment included measurements of BMD of FN and total hip (TH) using Lunar DPX (USA) and quantitative ultrasound (QUS) of hand phalanges by means of DBM Sonic 1200 (IGEA, Italy).
Results: Mean age did not differ between the subgroups, whereas height, weight, BMI and BMD were significantly higher in women with high BMD values. In women with high and low BMD, adiponectin concentration [μg/mL] was 24.81 ± 12.7 and 31.04 ± 12.64 respectively, and differed significantly (p < 0.05). Respective values for resistin concentration [ng/mL] were 3.29 ± 1.37 and 3.62 ± 1.45, and did not differ. Adiponectin negatively correlated with weight (r = –0.34, p < 0.01), BMI (r = –0.37, p < 0.01), FN BMD (r = –0.26, p < 0.05), TH BMD (r = –0.33, p < 0.01), and did not correlate with QUS result. Stepwise multiple regression analysis showed that TH BMD was negatively influenced by age and adiponectin and positively by weight, and that FN BMD was dependent on age and weight only.
Conclusions: Our results suggest that adiponectin may be an independent factor influencing skeletal status in women aged over 55 years. (Endokrynol Pol 2012; 63 (6): 427–431)
Abstract
Introduction: The aim of this study was to establish adiponectin and resistin serum levels and their relationship with skeletal status in women from the RAC-OST-POL study.
Material and methods: 40 women with the lowest and 40 women with the highest value of bone mineral density (BMD) measured at the femoral neck (FN) were selected from a total of 625 women after dividing them into six age categories. Mean age in the whole group of 80 women was 66.1 ± 8.0 years. 22 women had osteoporotic fractures. Adiponectin and resistin were measured, and skeletal assessment included measurements of BMD of FN and total hip (TH) using Lunar DPX (USA) and quantitative ultrasound (QUS) of hand phalanges by means of DBM Sonic 1200 (IGEA, Italy).
Results: Mean age did not differ between the subgroups, whereas height, weight, BMI and BMD were significantly higher in women with high BMD values. In women with high and low BMD, adiponectin concentration [μg/mL] was 24.81 ± 12.7 and 31.04 ± 12.64 respectively, and differed significantly (p < 0.05). Respective values for resistin concentration [ng/mL] were 3.29 ± 1.37 and 3.62 ± 1.45, and did not differ. Adiponectin negatively correlated with weight (r = –0.34, p < 0.01), BMI (r = –0.37, p < 0.01), FN BMD (r = –0.26, p < 0.05), TH BMD (r = –0.33, p < 0.01), and did not correlate with QUS result. Stepwise multiple regression analysis showed that TH BMD was negatively influenced by age and adiponectin and positively by weight, and that FN BMD was dependent on age and weight only.
Conclusions: Our results suggest that adiponectin may be an independent factor influencing skeletal status in women aged over 55 years. (Endokrynol Pol 2012; 63 (6): 427–431)
Keywords
adiponectin; bone mineral density; resistin
About this articleTitle
Adiponectin and resistin in relationship with skeletal status in women from the RAC-OST-POL study
Journal
Issue
Article type
Original paper
Pages
427-431
Published online
2013-01-02
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689
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1298
Bibliographic record
Endokrynol Pol 2012;63(6):427-431.
Keywords
adiponectin
bone mineral density
resistin
Authors
Wojciech Pluskiewicz
Piotr Adamczyk
Bogdan Marek
Aleksandra Czekajło
Bogna Drozdzowska
Dariusz Kajdaniuk
Beata Kos-Kudła
Władysław Grzeszczak
