open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15
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Determinants of atherosclerosis in children and adolescents with diabetes type 1

Sandra M. Stanković, Saša R. Živić, Ljiljana Šaranac, Vesna Cvetković, Milica Pešić, Karin Vasić, Miodrag Stanković, Aleksandra Topalović, Tatjana Cvetković
Endokrynologia Polska 2012;63(6):414-419.

open access

Vol 63, No 6 (2012)
Original papers
Published online: 2013-01-02
Submitted: 2013-02-15

Abstract


Introduction: To evaluate the degree of atherosclerosis in children and adolescents with type 1 diabetes and its correlation with risk factors, traditional and other, such as anti-oxidative capacity of circulating blood and level of lipid peroxidation.
Material and methods: Forty children and adolescents with type 1 diabetes with mean age 13.7 years were compared with 20 age- and sex-matched healthy control subjects. Association of carotid artery intima-media thickness (cIMT) with different risk factors measured in children with type 1 diabetes was evaluated.
Results: Mean carotid IMT was higher in subjects with diabetes (p < 0.01) and was strongly associated with total cholesterol with an odds ratio of 4.08 (p = 0.016), LDL-cholesterol with an odds ratio of 2.78 (p = 0.037), length of disease with an odds ratio of 1.87 (p = 0.007) and positive family history (first- and second-degree relatives) of diabetes and early CVD (heart attack and/or stroke before the age of 60 years) with an odds ratio of 6.8 (p = 0.007).
Conclusions: We found significantly increased cIMT in the diabetic patients compared to the healthy control subjects. Risk factors for the development of atherosclerosis included higher total and LDL-cholesterol, higher systolic blood pressure, positive family history of diabetes and early CVD and longer diabetes duration. In spite of the documented increased oxidative stress, we failed to establish a correlation between the oxidative stress parameters and cIMT values. (Endokrynol Pol 2012; 63 (6): 414&#8211;419)

Abstract


Introduction: To evaluate the degree of atherosclerosis in children and adolescents with type 1 diabetes and its correlation with risk factors, traditional and other, such as anti-oxidative capacity of circulating blood and level of lipid peroxidation.
Material and methods: Forty children and adolescents with type 1 diabetes with mean age 13.7 years were compared with 20 age- and sex-matched healthy control subjects. Association of carotid artery intima-media thickness (cIMT) with different risk factors measured in children with type 1 diabetes was evaluated.
Results: Mean carotid IMT was higher in subjects with diabetes (p < 0.01) and was strongly associated with total cholesterol with an odds ratio of 4.08 (p = 0.016), LDL-cholesterol with an odds ratio of 2.78 (p = 0.037), length of disease with an odds ratio of 1.87 (p = 0.007) and positive family history (first- and second-degree relatives) of diabetes and early CVD (heart attack and/or stroke before the age of 60 years) with an odds ratio of 6.8 (p = 0.007).
Conclusions: We found significantly increased cIMT in the diabetic patients compared to the healthy control subjects. Risk factors for the development of atherosclerosis included higher total and LDL-cholesterol, higher systolic blood pressure, positive family history of diabetes and early CVD and longer diabetes duration. In spite of the documented increased oxidative stress, we failed to establish a correlation between the oxidative stress parameters and cIMT values. (Endokrynol Pol 2012; 63 (6): 414&#8211;419)
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Keywords

determinants; atherosclerosis; children; diabetes type 1

About this article
Title

Determinants of atherosclerosis in children and adolescents with diabetes type 1

Journal

Endokrynologia Polska

Issue

Vol 63, No 6 (2012)

Pages

414-419

Published online

2013-01-02

Bibliographic record

Endokrynologia Polska 2012;63(6):414-419.

Keywords

determinants
atherosclerosis
children
diabetes type 1

Authors

Sandra M. Stanković
Saša R. Živić
Ljiljana Šaranac
Vesna Cvetković
Milica Pešić
Karin Vasić
Miodrag Stanković
Aleksandra Topalović
Tatjana Cvetković

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