open access

Vol 63, Supp. I (2012)
Postgraduate education
Published online: 2012-12-31
Submitted: 2013-02-15
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Psychological stress and the function of male gonads

Paweł Jóźków, Marek Mędraś

open access

Vol 63, Supp. I (2012)
Postgraduate education
Published online: 2012-12-31
Submitted: 2013-02-15

Abstract

Stress is generally a natural phenomenon that affects behaviour, physiological processes, and neuroendocrine, neurochemical, neurological and immune responses. Many somatic and mental disorders are thought to result from chronic stress. Stress-induced gonadal dysfunction is not restricted to humans, but is observed in all higher animals. Stress-induced gonadal dysfunction comprises disturbances of the hypothalamic-pituitary-gonadal axis and of spermatogenesis. Various stressors induce changes in the secretion of neurotransmitters and hormones, such as CRH, ADH, beta-endorphins, somatostatin, VIP, PRL, GH, TSH, dopamine, serotonin, neuropeptide Y, melatonin, ACTH, glucocorticosteroids, catecholamines and androgens. In acute stress, testicular function is principally modified by cytokines and fluctuating concentrations of gonadotropins, while in chronic stress, hypogonadotropic hypogonadism and disruption of spermatogenesis of varying severity, including spermatogenetic arrest, are observed. In spite of the decades-long interest in the relationships between psychological stress and the function of male gonads, many questions in this area remain unanswered. (Pol J Endocrinol 2012; 63 (zeszyt edukacyjny I) 1–6)

Abstract

Stress is generally a natural phenomenon that affects behaviour, physiological processes, and neuroendocrine, neurochemical, neurological and immune responses. Many somatic and mental disorders are thought to result from chronic stress. Stress-induced gonadal dysfunction is not restricted to humans, but is observed in all higher animals. Stress-induced gonadal dysfunction comprises disturbances of the hypothalamic-pituitary-gonadal axis and of spermatogenesis. Various stressors induce changes in the secretion of neurotransmitters and hormones, such as CRH, ADH, beta-endorphins, somatostatin, VIP, PRL, GH, TSH, dopamine, serotonin, neuropeptide Y, melatonin, ACTH, glucocorticosteroids, catecholamines and androgens. In acute stress, testicular function is principally modified by cytokines and fluctuating concentrations of gonadotropins, while in chronic stress, hypogonadotropic hypogonadism and disruption of spermatogenesis of varying severity, including spermatogenetic arrest, are observed. In spite of the decades-long interest in the relationships between psychological stress and the function of male gonads, many questions in this area remain unanswered. (Pol J Endocrinol 2012; 63 (zeszyt edukacyjny I) 1–6)
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Keywords

psychological stress; testis; gonadotropins; androgens; semen

About this article
Title

Psychological stress and the function of male gonads

Journal

Endokrynologia Polska

Issue

Vol 63, Supp. I (2012)

Pages

1-6

Published online

2012-12-31

Keywords

psychological stress
testis
gonadotropins
androgens
semen

Authors

Paweł Jóźków
Marek Mędraś

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