Vol 10, No 6 (2021)
Research paper
Published online: 2021-05-26
Impact of probiotic intake on the glycemic control, lipid profile and inflammatory markers among patients with type 2 diabetes mellitus
Clin Diabetol 2021;10(6):468-475.
Abstract
Background. Type 2 diabetes mellitus (T2DM) is
a chronic disease with many dramatic complications.
It has also been suggested that altered intestinal
microbiota leads to increased intestinal permeability
and mucosal immune response, contributing to the
development of diabetes. We aimed to investigate
the effect of introduction of probiotic products on
glycemic control and inflammatory markers among
patients with T2DM.
Methods. The present work was carried on 150 patients
with T2DM. The studied patients were subjected to
full history taking, clinical examination and laboratory
investigations including fasting blood glucose (FBG),
2 hours post prandial blood glucose (2hPP), glycated
hemoglobin (HbA1c), total cholesterol (TC), triglycerides
(TG), HDL-C, LDL-C, C-reactive protein (CRP), interleukin
6 (IL6) and tumor-necrosis factor alpha (TNF a).
They were divided into 3 groups each of 50 patients.
They were all instructed to eat well-balanced diet. The
first group was instructed to eat the well-balanced diet
only, the second group received 2 cups of yogurt daily
in addition to diet and the third group received one
teaspoonful yeast daily in addition to diet. The effect
of the intervention was evaluated after 16 weeks.
Results. Patients receiving yogurt and the patients
receiving yeast showed significant reduction of FBG,
HbA1c, IL6, TNF-a, CRP and significant elevation of HDL-C
compared to patients on diet only. The 3 groups showed
significant reduction in 2hPP blood glucose and LDL-C.
Conclusion. Probiotic intake in patients with T2DM has
beneficial effect on glycemic control, lipid profile and
inflammatory markers after 16 weeks.
Keywords: type 2 diabetesprobioticslipid profileinflammatory markersyeast
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