open access

Vol 10, No 6 (2021)
Research paper
Submitted: 2020-11-20
Accepted: 2021-01-28
Published online: 2021-12-28
Get Citation

Prevalence of celiac disease in patients with type 1 diabetes: a systematic review and meta-analysis

Ahmed Albatineh1, Fazel Dehvan2, Hossein Shariari2, Yousef Moradi2, Borhan Moradveisi2, Reza Ghanei Gheshlagh2
DOI: 10.5603/DK.2021.0055
·
Clinical Diabetology 2021;10(6):447-461.
Affiliations
  1. Kuwait University Faculty of Medicine
  2. Kurdistan University of Medical Sciences, Pasdaran Ave, Kurdistan University of Medical Science, 0098 Sanandaj, Iran, Islamic Republic Of

open access

Vol 10, No 6 (2021)
Original articles
Submitted: 2020-11-20
Accepted: 2021-01-28
Published online: 2021-12-28

Abstract

Background. Celiac disease (CD) is more prevalent among

type 1 diabetes (T1D) patients compared to the general

population and can be accompanied by hypoglycemia

episodes in T1D patients. Studies worldwide have reported

CD prevalence with large variability. This study aimed

to estimate the pooled prevalence of CD in T1D patients.

Methods. PubMed, Web of Science, Science Direct, and

Scopus were searched without time limitation using

the keywords: Celiac Disease, Gluten Enteropathy, Gluten-

Sensitive Enteropathy, Wheat Hypersensitivity, Tissue

Transglutaminase Antibody, Endomysial Antibody

Disease, Diabetes Mellitus, and IDDM. Random-effects

inverse variance-weighted model, subgroup analysis,

and meta-regression were implemented. Heterogeneity

was examined using Cochran’s Q test and I2 statistics.

Results. A pooled analysis of 55 articles with total

sample size 71,853 revealed that the CD prevalence in

patients with T1D was 5.08% (95% CI: 4.44%, 5.73%)

with large heterogeneity (I2 = 84%). To account for

publication bias, using trim-and-fill method, the

pooled prevalence was 4.0% (95% CI: 3.38%, 4.73%).

The prevalence of CD was higher in Asia (6.53%, 95%

CI: 4.89%, 8.16%) compared to USA (4.89%, 95% CI:

3.85%, 5.93%) and Europe (4.76%, 95% CI: 3.78%,

5.74%). In addition, studies conducted after 2008

reported pooled prevalence (6.37%, 95% CI: 5.25%,

7.49%) significantly higher than those conducted before

2008 (4.14%, 95% CI: 3.19%, 5.09%). Studies with

quality score 10 had significantly higher prevalence

(7.0%, 95% CI: 5.04%, 8.96%) compared with quality

score 7 (3.66%, 95% CI: 2.61%, 4.70%).

Conclusion. CD is highly prevalent in T1D patients.

Studies from Asia, those published after the year 2008,

and studies with quality score 10 had higher pooled

CD prevalence. Therefore, early screening for CD in T1D

patients is important to prevent complications of CD.

Abstract

Background. Celiac disease (CD) is more prevalent among

type 1 diabetes (T1D) patients compared to the general

population and can be accompanied by hypoglycemia

episodes in T1D patients. Studies worldwide have reported

CD prevalence with large variability. This study aimed

to estimate the pooled prevalence of CD in T1D patients.

Methods. PubMed, Web of Science, Science Direct, and

Scopus were searched without time limitation using

the keywords: Celiac Disease, Gluten Enteropathy, Gluten-

Sensitive Enteropathy, Wheat Hypersensitivity, Tissue

Transglutaminase Antibody, Endomysial Antibody

Disease, Diabetes Mellitus, and IDDM. Random-effects

inverse variance-weighted model, subgroup analysis,

and meta-regression were implemented. Heterogeneity

was examined using Cochran’s Q test and I2 statistics.

Results. A pooled analysis of 55 articles with total

sample size 71,853 revealed that the CD prevalence in

patients with T1D was 5.08% (95% CI: 4.44%, 5.73%)

with large heterogeneity (I2 = 84%). To account for

publication bias, using trim-and-fill method, the

pooled prevalence was 4.0% (95% CI: 3.38%, 4.73%).

The prevalence of CD was higher in Asia (6.53%, 95%

CI: 4.89%, 8.16%) compared to USA (4.89%, 95% CI:

3.85%, 5.93%) and Europe (4.76%, 95% CI: 3.78%,

5.74%). In addition, studies conducted after 2008

reported pooled prevalence (6.37%, 95% CI: 5.25%,

7.49%) significantly higher than those conducted before

2008 (4.14%, 95% CI: 3.19%, 5.09%). Studies with

quality score 10 had significantly higher prevalence

(7.0%, 95% CI: 5.04%, 8.96%) compared with quality

score 7 (3.66%, 95% CI: 2.61%, 4.70%).

Conclusion. CD is highly prevalent in T1D patients.

Studies from Asia, those published after the year 2008,

and studies with quality score 10 had higher pooled

CD prevalence. Therefore, early screening for CD in T1D

patients is important to prevent complications of CD.

Get Citation

Keywords

type 1 diabetes, celiac disease, prevalence, meta-analysis

About this article
Title

Prevalence of celiac disease in patients with type 1 diabetes: a systematic review and meta-analysis

Journal

Clinical Diabetology

Issue

Vol 10, No 6 (2021)

Article type

Research paper

Pages

447-461

Published online

2021-12-28

Page views

1374

Article views/downloads

178

DOI

10.5603/DK.2021.0055

Bibliographic record

Clinical Diabetology 2021;10(6):447-461.

Keywords

type 1 diabetes
celiac disease
prevalence
meta-analysis

Authors

Ahmed Albatineh
Fazel Dehvan
Hossein Shariari
Yousef Moradi
Borhan Moradveisi
Reza Ghanei Gheshlagh

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