The acute effect of a moderate intensity ergocycle exercise on the coagulation parameters in type 2 diabetes mellitus patients: a feasibility study
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Abstract
Background. Type 2 diabetes mellitus (T2DM) patients experience higher atherothrombotic risks that could lead to cardiovascular diseases, due to increases in coagulation activities. The role of exercise in altering coagulation activities among T2DM patients is still inconclusive. This feasibility study aimed to evaluate the immediate effect of a moderate intensity ergocycle exercise, primary on the coagulation parameters and secondary on the systemic inflammation and blood glucose, in otherwise healthy T2DM patients.
Methods. Ten T2DM patients (64 ± 7 year, 40% female) performed a 30-minute moderate-intensity ergocycle exercise at 50–60% of heart rate reserved. Coagulation parameters (activated partial thromboplastin time [aPTT], prothrombin time [PT] and platelet count), erythrocyte sedimentation rate, and blood glucose were assessed before the exercise (T0), immediately after the exercise (T1), and 30 minutes post exercise (T2). One-way repeated measured ANOVA was used to assess the outcomes over time.
Results. All participants completed and adhered to the exercise protocol. There were increases in aPTT and PT but decreases in platelet count at T1 and T2 compared to at T0 (P < 0.05), indicating reduction in the coagulation activities. Those values, however, were still within normal ranges. The erythrocyte sedimentation rates were unaffected, while blood glucose decreased from 202 ± 35 mg/dL at T0 to 173 ± 33 mg/dL and 158 ± 30 mg/dL at T1 and T2 (P < 0.01).
Conclusion. The 30-minute moderate-intensity ergocycle decreases coagulation activities and blood glucose but does not affect erythrocyte sedimentation rates in T2DM patients. Future studies should focus on the chronic adaptation of the coagulation parameters after ergocycle training among a T2DM patients with coagulation impairments.
Keywords: activated partial thromboplastin timeprothrombin timeplateleterythrocyte sedimentation rate
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