Vol 8, No 6 (2019)
Review article
Published online: 2020-01-23

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Review of nuclear medicine methods applied in diabetology

Paulina Cegła1, Dorota Pisarczyk-Wiza2, Krzysztof Matuszewski3, Kamila Witkowska4, Natalia Bocer1, Katarzyna Pietrasz1, Aleksandra Kaczmarek15, Dorota Zozulińska-Ziółkiewicz2
Clin Diabetol 2019;8(6):303-309.

Abstract

The aim of this paper is to present the most relevant clinical applications of positron emission tomography/computed tomography, scintigraphy and single photon emission tomography with different radiotracers allowing to visualize e.g. glucose metabolism, amino acids metabolism, receptor density or inflammation and infections in diabetology.

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References

  1. https://stat gov pl/infografiki-widzety/infografiki/infografika-swiatowy-dzien-walki-z-cukrzyca-14-listopada,46,2 html. (odwiedzone 21.04.2019).
  2. Almakiewiz R, Szostak S, Birkenfeld B. Podstawy fizyki promieniowania. In: Birkenfeld B, Listewnik M (ed.). Medycyna nuklearna, obrazowanie molekularne. Wydawnictwo Pomorskiego Uniwersytetu Medycznego w Szczecinie, Szczecin 2011: 152–161.
  3. Wernick MN, Aarsvold JN. Emission tomography. The fundamentals of PET and SPECT. San Diego: Elsevier Academic Press. 2004.
  4. Peleg AY, Weerarathna T, McCarthy JS, et al. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 2007; 23(1): 3–13.
  5. Kemper J, Kuijper EJ, Mirck PG, et al. Recovery from rhinocerebral mucormycosis in a ketoacidotic diabetic patient: a case report. J Laryngol Otol. 1993; 107(3): 233–235.
  6. Carfrae MJ, Kesser BW. Malignant otitis externa. Otolaryngol Clin North Am. 2008; 41(3): 537–549.
  7. Bhansali A, Sridhar C, Choudhary S. Type 2 diabetes, emphysematous pyelonephritis and emphsematous cholecystitis. J Assoc Physicians India. 2004; 52: 124.
  8. Sella EJ. Current concepts review: diagnostic imaging of the diabetic foot. Foot Ankle INT. 2009; 30: 568–576.
  9. Rajbhandari SM, Jenkins RC, Davies C, Tesfaye S. Charcot neuroarthropathy in diabetes mellitus. Diabetologia. 2002; 45: 1085–1096.
  10. Keenan AM, Tindel NL, Alavi A. Diagnosis of pedal osteomyelitis in diabetic patients using current scintigraphic techniques. Arch Intern Med. 1989; 149: 2262–2266.
  11. Alazraki N, Deries D, Datz F, et al. Value of 24-hour image (four phase bone scan) in assessing osteomyelitis in patients with peripheral vascular disease. J Nucl Med. 1985; 26: 711–717.
  12. Israel O, Gips S, Jerushalmi J, et al. Osteomyelitis and soft-tissue infection: differential diagnosis with 24 hour/4 hour ratio of Tc-99m MDP uptake. Radiology. 1987; 163(3): 725–726.
  13. Blume P, Dey H, Daley L, et al. Diagnosis of pedal osteomyelitis with Tc-99m HMPAO labeled leukocytes. J Foot Ankle Sugr. 1997; 36(2): 120–126.
  14. Devillers A, Garin E, Polard JL, et al. Comparison of Tc-99m-labelled antileukocyte fragment Fab' and Tc-99m-HMPAO leukocyte scintigraphy in the diagnosis of bone and joint infections: a prospective study. Nucl Med Commun. 2000; 21(8): 747–753.
  15. Poirier JY, Garin E, Derrien C, et al. Diagnosis of osteomyelitis in the diabetic foot with 99mTC-HMPAO leukocyte scintigraphy combined with a 99mTc-MDP bone scintigraphy. Diabetes Metab. 2002; 28: 485–490.
  16. Hage FG, Lusa L, Dondi M, et al. IAEA Diabetes Investigators. Exercise stress tests for detecting myocardial ischemia in asymptomatic patients with diabetes mellitus. Am J Cardiol. 2013; 112(1): 14–20.
  17. Farmer AD, Bruckner-Holt C, Schwartz S, et al. Diabetic Gastroparesis: Perspectives From a Patient and Health Care Providers. J Patient Cent Res Rev. 2019; 6(2): 148–157.
  18. Krzyżewska M, Maroszek P, Mrozikiewicz-Rakowska B, et al. Diabetic gastroparesis: do you know how to recognize and effectively treat? Diabet Klin. 2014; 3: 157–166.
  19. Strashun AM, Najatheim M, Goldsmith SJ. Malignant external otitis: Elary scintigraphic detection. Radiology 1984; 150: 541–545.
  20. Birkenfeld B, Kozłowska I, Listewnik M. Badania scyntygraficzne nerek. In: Medycyna nuklerana, obrazowanie molekularne. 90–98.
  21. Rossleigh MA. Scintigraphic imaging in renal infections. Q J Nucl Med Mol Imaging. 2009; 53: 72–77.
  22. Elbl B, Birkenfeld B, Kozłowska I. Badania radioizotopowe przewodu pokarmowego. In: Medycyna nuklerana, obrazowanie molekularne. 69–78.
  23. Kalimi R, Gecelter GR, Caplin D, et al. Diagnosis of acute cholecystitis: sensitivity of sonography, cholescintigraphy and combined sonography-cholescintigraphy. J AM Coll Surg. 2001; 193: 609–613.
  24. Saha G. Physics and radiobiology of nuclear medicine. 2006.
  25. National Research Council and Institute of Medicine. Advancing Nuclear Medicine Through Innovation. Washington: The National Academies Press. 2007.
  26. Fogelman I, Gnanasegaran G, Van de. Radionuclide and hybrid bone imaging. Springer-Verlag, Berlin. 2013.
  27. Antunes P, Ginj M, Zhang H, et al. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? Eur J Nucl Med Mol Imaging. 2007; 34(7): 982–993.
  28. Dziennik Urzędowy Ministra Zdrowia, Obwieszczenie Ministra Zdrowia z dnia 22 grudnia 2014 w sprawie ogłoszenia wykazu wzorcowych procedur radiologicznych z zakresu medycyny nuklearnej.
  29. Ismail D, Hussain K. Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism. Rev Endocr Metab Disord. 2010; 11(3): 165–169.
  30. Buraczewska M, Brandt A, Kopacz K.E, Myśliwiec M. Znaczenie diagnostyki obrazowej wrodzonego hiperinsulinizmu u rodzeństwa. Endokrynol Ped. 2015; 14: 47–50.
  31. Arnoux JB, Verkarre V, Saint-Martin C, et al. Congenital hyperinsulinism: current trends in diagnosis and therapy. Orphanet J Rare Dis. 2011; 6: 63.
  32. Körner M, Christ E, Wild D, et al. Glucagon-like peptide-1 receptor overexpression in cancer and its impact on clinical applications. Front Endocrinol (Lausanne). 2012; 3: 158.
  33. Antwi K, Fani M, Nicolas G, et al. Localization of Hidden Insulinomas with ⁶⁸Ga-DOTA-Exendin-4 PET/CT: A Pilot Study. J Nucl Med. 2015; 56(7): 1075–1078.
  34. Luo Y, Yu M, Pan Q, et al. 68Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake. Eur J Nucl Med Mol Imaging. 2015; 42(3): 531–532.
  35. Luo Y, Pan Q, Yao S, et al. Glucagon-like peptide-1 receptor PET/CT with 68Ga-NOTA-Exendin-4 for detecting localized insulinoma: a prospective cohort study. J Nucl Med. 2016; 57(5): 715–720.
  36. Wiehr S, Warnke P, Rolle AM, et al. New pathogen-specific immunoPET/MR tracer for molecular imaging of a systemic bacterial infection. Oncotarget. 2016; 7(10): 10990–11001.
  37. Romero Pastrana F, Thompson JM, Heuker M, et al. Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe. Virulence. 2018; 9(1): 262–272.
  38. Pickett JE, Thompson JM, Sadowska A, et al. Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone. Bone Res. 2018; 6: 13.
  39. Sellmyer MA, Lee I, Hou C, et al. Bacterial infection imaging with [F]fluoropropyl-trimethoprim. Proc Natl Acad Sci U S A. 2017; 114(31): 8372–8377.
  40. Ocampo IZ, de Queiroz Souza Passos P, Ramirez de Carvalho L, et al. In vitro cytotoxic and genotoxic evaluation of peptides used in nuclear medicine (DOTATATE and Ubiquicidin) in CHO-K1 cells. Cytotechnology. 2016; 68(6): 2301–2310.
  41. Carrasco-Hernandez J, SolÃs-Lara H, Altamirano-Ley J, et al. Measured human dosimetry of 68Ga-DOTA-UBI 29–41, a potential tracer for imaging bacterial infection processes. J Nucl Med. 2016; 57: 1020.
  42. Zhang Z, Ordonez AA, Wang H, et al. Positron Emission Tomography Imaging with 2-[F]F- p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response. ACS Infect Dis. 2018; 4(11): 1635–1644.
  43. Neumann KD, Villanueva-Meyer JE, Mutch CA, et al. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017; 7(1): 7903.
  44. Petrik M, Zhai C, Haas H, et al. Siderophores for molecular imaging applications. Clin Transl Imaging. 2017; 5(1): 15–27.
  45. Li J, Zheng H, Fodah R, et al. Validation of 2-F-fluorodeoxysorbitol as a potential radiopharmaceutical for imaging bacterial infection in the lung. J Nucl Med. 2018; 59(1): 134–139.
  46. Bini J, Naganawa M, Nabulsi N, et al. Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of C-(+)-PHNO. J Nucl Med. 2018; 59(8): 1249–1254.