open access

Vol 8, No 6 (2019)
ORIGINAL ARTICLES
Published online: 2020-01-23
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Role of serum allograft inflammatory factor-1 (AIF-1) in Egyptian type 2 diabetic patients

Mona Kamal ElDeeb, Gihane Ibrahim Khalil, Moatez Ahmed Zaki, El-Sayed Mehana, Sahar Omer
DOI: 10.5603/DK.2019.0025
·
Clinical Diabetology 2019;8(6):271-276.

open access

Vol 8, No 6 (2019)
ORIGINAL ARTICLES
Published online: 2020-01-23

Abstract

Background. Diabetes mellitus (DM) is a powerful and independent risk factor for cardiovascular disease. The atherosclerosis process in diabetes is indistinguishable from that of the nondiabetic population, but it begins earlier and is often more extensive and more severe. AIF-1 promotes chemotaxis, spreading and migration of macrophages and vascular smooth muscle cells (VSMCs) which suggest a role of AIF-1 in the atherosclerotic plaque formation. Thus, this study determines the role of AIF-1 in the Egyptian type 2 diabetic patients.

Results. The level of AIF-1 was significantly higher in the type 2 diabetic group when compared to the control group (p = 0.000). In type 2 diabetic patients group, there was a significant positive correlation between CIMT and AIF-1 (r = 0.468, p = 0.000). In addition to the positive correlation between CIMT and AIF-1, CIMT in regression model analysis was significantly positive contributing to the outcome variable (AIF-1) (p < 0.05), denoting the possible role of elevated serum AIF-1 level in atherosclerotic process with further studies on larger scale needed.

Abstract

Background. Diabetes mellitus (DM) is a powerful and independent risk factor for cardiovascular disease. The atherosclerosis process in diabetes is indistinguishable from that of the nondiabetic population, but it begins earlier and is often more extensive and more severe. AIF-1 promotes chemotaxis, spreading and migration of macrophages and vascular smooth muscle cells (VSMCs) which suggest a role of AIF-1 in the atherosclerotic plaque formation. Thus, this study determines the role of AIF-1 in the Egyptian type 2 diabetic patients.

Results. The level of AIF-1 was significantly higher in the type 2 diabetic group when compared to the control group (p = 0.000). In type 2 diabetic patients group, there was a significant positive correlation between CIMT and AIF-1 (r = 0.468, p = 0.000). In addition to the positive correlation between CIMT and AIF-1, CIMT in regression model analysis was significantly positive contributing to the outcome variable (AIF-1) (p < 0.05), denoting the possible role of elevated serum AIF-1 level in atherosclerotic process with further studies on larger scale needed.

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Keywords

allograft inflammatory factor-1 (AIF-1), diabetes mellitus (DM), atherosclerosis, inflammation

About this article
Title

Role of serum allograft inflammatory factor-1 (AIF-1) in Egyptian type 2 diabetic patients

Journal

Clinical Diabetology

Issue

Vol 8, No 6 (2019)

Pages

271-276

Published online

2020-01-23

DOI

10.5603/DK.2019.0025

Bibliographic record

Clinical Diabetology 2019;8(6):271-276.

Keywords

allograft inflammatory factor-1 (AIF-1)
diabetes mellitus (DM)
atherosclerosis
inflammation

Authors

Mona Kamal ElDeeb
Gihane Ibrahim Khalil
Moatez Ahmed Zaki
El-Sayed Mehana
Sahar Omer

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