open access

Vol 5, No 1 (2016)
Original articles (submitted)
Get Citation

Patient adherence to and tolerability of treatment with metformin extended-release formulation in patients with type 2 diabetes. GLUCOMP study

Krzysztof Strojek, Anna Kurzeja, Ulrike Gottwald-Hostalek
DOI: 10.5603/DK.2016.0003
·
Clinical Diabetology 2016;5(1):15-21.

open access

Vol 5, No 1 (2016)
Original articles (submitted)

Abstract

Introduction. Appropriate treatment of diabetes requires regular intake of recommended drugs. Multifactorial therapy, which necessitates the concomitant use of many medications, may decrease patient adherence. The purpose of the study was to assess type 2 diabetic patients’ adherence to and tolerability of metformin extended-release formulation in the outpatient setting.

Materials and methods. This non-interventional study was conducted in a group of 4737 patients [including 2468 (52%) women] with mean age of 60.6 ± 9.4 years, diabetes duration of 5.6 ± 4.4 years, duration of treatment with metformin extended release formulation of 8.3 ± 12 months at an average dose of 1667 ± 350 mg. The study enrolled patients aged over 18 years with type 2 diabetes if they were treated with metformin extended- release formulation at a dose of 1500–2000 mg for less than 1 year prior to the study enrollment. The exclusion criteria included: pregnancy, breast-feeding and any contraindications for metformin treatment. Treatment adherence was assessed by a tablet count (percentage of prescribed tablets taken) and using the Morisky-Green scale. Treatment adherence was defined as follows: excellent patient adherence if > 90% of prescribed tablets were taken; good: 76–90%; moderate: 51–75%; poor: ≤ 50%. Treatment tolerability was also evaluated based on the medical history focused on gastrointestinal symptoms, as well as patient preference for using specific types of metformin. Other patient data, clinical data and laboratory test results were recorded at the beginning of the study and after 3 months.

Results. After 3 months of treatment with metformin extended release formulation 96% of study subjects demonstrated excellent or good adherence. Treatment adherence was significantly lower with 2 or 3 concomitant medications as compared to one (p < 0.001). Adverse events occurred in 715 patients (15% out of 4758 patients undergoing safety analysis). The occurrence of adverse events significantly decreased treatment adherence (p < 0.001). Approximately 90% of patients declared they had preferred the use of metformin extended-release formulation.

Conclusions. Metformin extended-release formulation is a suitable, well tolerated therapeutic option which helps to obtain good patient cooperation based on good adherence. (

Abstract

Introduction. Appropriate treatment of diabetes requires regular intake of recommended drugs. Multifactorial therapy, which necessitates the concomitant use of many medications, may decrease patient adherence. The purpose of the study was to assess type 2 diabetic patients’ adherence to and tolerability of metformin extended-release formulation in the outpatient setting.

Materials and methods. This non-interventional study was conducted in a group of 4737 patients [including 2468 (52%) women] with mean age of 60.6 ± 9.4 years, diabetes duration of 5.6 ± 4.4 years, duration of treatment with metformin extended release formulation of 8.3 ± 12 months at an average dose of 1667 ± 350 mg. The study enrolled patients aged over 18 years with type 2 diabetes if they were treated with metformin extended- release formulation at a dose of 1500–2000 mg for less than 1 year prior to the study enrollment. The exclusion criteria included: pregnancy, breast-feeding and any contraindications for metformin treatment. Treatment adherence was assessed by a tablet count (percentage of prescribed tablets taken) and using the Morisky-Green scale. Treatment adherence was defined as follows: excellent patient adherence if > 90% of prescribed tablets were taken; good: 76–90%; moderate: 51–75%; poor: ≤ 50%. Treatment tolerability was also evaluated based on the medical history focused on gastrointestinal symptoms, as well as patient preference for using specific types of metformin. Other patient data, clinical data and laboratory test results were recorded at the beginning of the study and after 3 months.

Results. After 3 months of treatment with metformin extended release formulation 96% of study subjects demonstrated excellent or good adherence. Treatment adherence was significantly lower with 2 or 3 concomitant medications as compared to one (p < 0.001). Adverse events occurred in 715 patients (15% out of 4758 patients undergoing safety analysis). The occurrence of adverse events significantly decreased treatment adherence (p < 0.001). Approximately 90% of patients declared they had preferred the use of metformin extended-release formulation.

Conclusions. Metformin extended-release formulation is a suitable, well tolerated therapeutic option which helps to obtain good patient cooperation based on good adherence. (

Get Citation

Keywords

type 2 diabetes; metformin extended-release formulation; treatment; adherence; adverse events

About this article
Title

Patient adherence to and tolerability of treatment with metformin extended-release formulation in patients with type 2 diabetes. GLUCOMP study

Journal

Clinical Diabetology

Issue

Vol 5, No 1 (2016)

Pages

15-21

DOI

10.5603/DK.2016.0003

Bibliographic record

Clinical Diabetology 2016;5(1):15-21.

Keywords

type 2 diabetes
metformin extended-release formulation
treatment
adherence
adverse events

Authors

Krzysztof Strojek
Anna Kurzeja
Ulrike Gottwald-Hostalek

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl